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严重双侧有症状颈内动脉狭窄的管理:病例报告及文献综述

Management of Severe Bilateral Symptomatic Internal Carotid Artery Stenosis: Case Report and Literature Review.

作者信息

Robu Mircea, Radulescu Bogdan, Margarint Irina-Maria, Dragan Anca, Stiru Ovidiu, Gorecki Gabriel-Petre, Voica Cristian, Iliescu Vlad Anton, Moldovan Horatiu

机构信息

Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

1st Department of Cardiovascular Anesthesiology and Intensive Care, Prof. Dr. C. C. Iliescu Emergency Institute for Cardiovascular Diseases, 022328 Bucharest, Romania.

出版信息

J Pers Med. 2024 Aug 23;14(9):893. doi: 10.3390/jpm14090893.

Abstract

Multiple strategies for tandem severe carotid artery stenosis are reported: bilateral carotid artery endarterectomy (CEA), bilateral carotid artery stenting (CAS), and hybrid procedures (CEA and CAS). The management is controversial, considering the reported high risk of periprocedural stroke, hemodynamic distress, and cerebral hyperperfusion syndrome. We present the case of a 64-year-old patient with severe symptomatic bilateral internal carotid artery stenosis (95% stenosis on the left internal carotid artery with recent ipsilateral watershed anterior cerebral artery-medial cerebral artery (ACA-MCA) and medial cerebral artery-posterior cerebral artery (MCA-PCA) ischemic strokes and 90% stenosis on the right internal carotid artery with chronic ipsilateral frontal ischemic stroke) managed successfully with staged CEA within a 3-day interval. The patient had a history of coronary angioplasty and stenting. Strategies for brain protection included shunt placement after the evaluation of carotid stump pressure, internal carotid backflow, and near-infrared spectroscopy. A collagen and silver-coated polyester patch was used to complete the endarterectomy using a 6.0 polypropylene continuous suture in both instances. Management also included neurological consults after extubation, dual antiplatelet therapy, head CT between the two surgeries, myocardial ischemia monitoring, and general anesthesia. Staged CEA with a small time interval between surgeries can be an option to treat tandem symptomatic carotid artery stenosis in highly selected patients. The decision should be tailored according to the patient's characteristics and should also be made by a cardiology specialist, a neurology specialist, and an anesthesia and intensive care physician.

摘要

已有多种针对串联性重度颈动脉狭窄的治疗策略被报道

双侧颈动脉内膜切除术(CEA)、双侧颈动脉支架置入术(CAS)以及杂交手术(CEA联合CAS)。鉴于报道中围手术期卒中、血流动力学窘迫及脑过度灌注综合征的高风险,其治疗存在争议。我们报告了一例64岁患者,患有严重症状性双侧颈内动脉狭窄(左侧颈内动脉狭窄95%,近期同侧分水岭区大脑前动脉-大脑中动脉(ACA-MCA)及大脑中动脉-大脑后动脉(MCA-PCA)缺血性卒中;右侧颈内动脉狭窄90%,伴有同侧慢性额叶缺血性卒中),在3天内分阶段成功实施了CEA。该患者有冠状动脉血管成形术和支架置入史。脑保护策略包括在评估颈动脉残端压力、颈内动脉反流及近红外光谱后放置分流管。在两个手术中均使用胶原蛋白和银涂层聚酯补片,采用6.0聚丙烯连续缝线完成内膜切除术。治疗还包括拔管后进行神经科会诊、双联抗血小板治疗、两次手术之间进行头颅CT检查、心肌缺血监测以及全身麻醉。在高度选择的患者中,手术间隔时间较短的分阶段CEA可作为治疗串联性症状性颈动脉狭窄的一种选择。决策应根据患者的具体情况量身定制,并且应由心脏病专家、神经科专家以及麻醉和重症监护医师共同做出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11432853/93b744f7d01c/jpm-14-00893-g001.jpg

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