Telegrafo Michele, Stucci Stefania Luigia, Gurrado Angela, Catacchio Claudia, Cofone Federico, Maruccia Michele, Stabile Ianora Amato Antonio, Moschetta Marco
Breast Care Unit, University Hospital Consortium Policlinico of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Aldo Moro University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy.
J Pers Med. 2024 Aug 31;14(9):930. doi: 10.3390/jpm14090930.
Neoadjuvant chemotherapy (NAC) is currently used for treating breast cancer in selected cases. Our study aims to evaluate the role of automated breast ultrasound (ABUS) in the assessment of response to NAC and compare the ABUS results with MRI. A total of 52 consecutive patients were included in this study. ABUS and MRI sensitivity (SE), specificity (SP), diagnostic accuracy (DA), positive predictive value (PPV), and negative predictive value (NPV) were calculated and represented using Area Under ROC Curve (ROC) analysis, searching for any significant difference ( < 0.05). The McNemar test was used searching for any significant difference in terms of sensitivity by comparing the ABUS and MRI results. The inter-observer agreement between the readers in evaluating the response to NAC for both MRI and ABUS was calculated using Cohen's kappa k coefficient. A total of 35 cases of complete response and 17 cases of persistent disease were found. MRI showed SE, SP, DA, PPV, and NPV values of 100%, 88%, 92%, 81%, and 100%, respectively, with an AUC value of 0.943 ( < 0.0001). ABUS showed SE, SP, DA, PPV, and NPV values of 88%, 94%, 92%, 89%, and 94%, respectively, with an AUC of 0.913 ( < 0.0001). The McNemar test revealed no significant difference ( = 0.1250). The inter-observer agreement between the two readers in evaluating the response to NAC for MRI and ABUS was, respectively, 0.88 and 0.89. Automatic breast ultrasound represents a new accurate, tri-dimensional and operator-independent tool for evaluating patients referred to NAC.
新辅助化疗（NAC）目前用于特定病例的乳腺癌治疗。我们的研究旨在评估自动乳腺超声（ABUS）在评估NAC反应中的作用，并将ABUS结果与MRI结果进行比较。本研究共纳入52例连续患者。计算ABUS和MRI的敏感性（SE）、特异性（SP）、诊断准确性（DA）、阳性预测值（PPV）和阴性预测值（NPV），并使用ROC曲线下面积（ROC）分析进行表示，寻找任何显著差异（<0.05）。使用McNemar检验通过比较ABUS和MRI结果来寻找敏感性方面的任何显著差异。使用Cohen's kappa k系数计算两位阅片者在评估MRI和ABUS对NAC反应时的观察者间一致性。共发现35例完全缓解病例和17例疾病持续存在病例。MRI显示SE、SP、DA、PPV和NPV值分别为100%、88%、92%、81%和100%，AUC值为0.943（<0.0001）。ABUS显示SE、SP、DA、PPV和NPV值分别为88%、94%、92%、89%和94%
