Spinato Giacomo, Schiavon Valentina, Torvilli Sara, Carraro Stefano, Amato Federica, Daloiso Antonio, Di Fiore Adolfo, Favero Vittorio, Franz Leonardo, Marioni Gino, de Filippis Cosimo, Fabbris Cristoforo, Emanuelli Enzo, Nicolai Piero
Department of Neuroscience, Section of Otolaryngology, University of Padova, 35121 Padova, Italy.
Department of Neuroscience, School of Dentistry, University of Padova, 35121 Padova, Italy.
J Pers Med. 2024 Sep 23;14(9):1013. doi: 10.3390/jpm14091013.
This review aims to provide a comprehensive overview of the literature on the oral side effects caused by radiotherapy for head and neck cancers. Various treatments are examined to mitigate these sequelae, and a protocol is proposed for dentists and dental hygienists to manage oncological patients. A literature search was conducted to select relevant articles addressing the effects of radiotherapy treatments on the oral cavity, with a particular focus on the development of mucositis, candidiasis, changes in salivary pH, trismus, fibrosis, and alterations in the oral biofilm. PubMed and MedLine were used as search engines, with keyword combinations including: head and neck cancer, mucositis, candida, dental care, dental hygiene, epidemiology, oral microbiome, biofilm, trismus, fibrosis, and salivary pH. A total of 226 articles were identified, spanning the period from 1998 to 2023. Articles deemed inappropriate or in languages other than English or Italian were excluded. A management protocol for oncological patients was proposed, divided into two phases: home-based and professional. Despite the advancements in intensity-modulated radiation therapy, it is impossible to completely avoid damage to healthy tissues. Preventive education and counseling in the dental chair, ongoing motivation, and education about oral hygiene are crucial to combine a good therapeutic outcome with an improved quality of life for the patient.
本综述旨在全面概述有关头颈部癌症放射治疗引起的口腔副作用的文献。研究了各种减轻这些后遗症的治疗方法,并为牙医和口腔保健员提出了管理肿瘤患者的方案。进行了文献检索,以选择涉及放射治疗对口腔影响的相关文章,特别关注粘膜炎、念珠菌病、唾液pH值变化、牙关紧闭、纤维化以及口腔生物膜改变的发展情况。使用PubMed和MedLine作为搜索引擎,关键词组合包括:头颈部癌症、粘膜炎、念珠菌、牙科护理、口腔卫生、流行病学、口腔微生物群、生物膜、牙关紧闭、纤维化和唾液pH值。共确定了226篇文章,时间跨度从1998年到2023年。排除了被认为不合适或语言不是英语或意大利语的文章。提出了一个针对肿瘤患者的管理方案,分为两个阶段:家庭阶段和专业阶段。尽管调强放射治疗取得了进展,但完全避免对健康组织的损害是不可能的。在牙科治疗椅上进行预防教育和咨询、持续的激励以及口腔卫生教育对于将良好的治疗效果与改善患者生活质量相结合至关重要。