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氧化铜纳米颗粒作为纳米载体及其抗菌效果。

CuO Nanoparticles as Nanocarriers and Its Antibacterial Efficacy.

作者信息

Torres-Ramos María Isabel, Martín-Camacho Ubaldo de Jesús, Sánchez-Burgos Jorge Alberto, Ghotekar Suresh, González-Vargas Oscar Arturo, Fellah Mamoun, Pérez-Larios Alejandro

机构信息

Nanomaterials, Water and Energy Research Laboratory, Centro de Estudios para la Agricultura, la Alimentación y la Crisis Climática (CEAACC), Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos 47600, Mexico.

Integral Food Research Laboratory, National Technological of Mexico/Technological Institute of Tepic, Tepic 63175, Mexico.

出版信息

Pharmaceuticals (Basel). 2024 Aug 26;17(9):1124. doi: 10.3390/ph17091124.

Abstract

In this study, CuO nanoparticles were synthesized using the sol-gel technique and subsequently functionalized with extracts from plants of the Rauvolfioideae subfamily and citrus fruits. Comprehensive characterization techniques, including UV-Vis spectroscopy, FT-IR, XRD, BET, SEM, and TEM, were employed to evaluate the structural and surface properties of the synthesized nanoparticles. The results demonstrated that both functionalized CuO nanoparticles exhibit mesoporous structures, as confirmed by nitrogen adsorption-desorption isotherms and the pore size distribution analysis. The green extract functionalized nanoparticles displayed a more uniform pore size distribution compared to those functionalized with the orange extract. The study underscores the potential of these functionalized CuO nanoparticles for applications in drug delivery, catalysis, and adsorption processes, highlighting the influence of the functionalization method on their textural properties and performance in antibacterial efficacy.

摘要

在本研究中,采用溶胶-凝胶技术合成了氧化铜纳米颗粒,随后用萝芙木亚科植物和柑橘类水果的提取物对其进行功能化处理。采用包括紫外-可见光谱、傅里叶变换红外光谱、X射线衍射、比表面积分析仪、扫描电子显微镜和透射电子显微镜在内的综合表征技术,来评估合成纳米颗粒的结构和表面性质。结果表明,两种功能化的氧化铜纳米颗粒均呈现介孔结构,这通过氮气吸附-脱附等温线和孔径分布分析得以证实。与用橙子提取物功能化的纳米颗粒相比,绿色提取物功能化的纳米颗粒显示出更均匀的孔径分布。该研究强调了这些功能化氧化铜纳米颗粒在药物递送、催化和吸附过程中的应用潜力,突出了功能化方法对其结构性质和抗菌功效性能的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca54/11605230/e68918bc7657/pharmaceuticals-17-01124-g001.jpg

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