Goodnight J E, Moseley H S, Eilber F R, Sarna G, Morton D L
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2005-7.
Twenty-one patients with disseminated malignant melanoma were treated with cis-dichlorodiammine-platinum(II) (cis-DDP): ten with cis-DDP alone at a dose of 20 mg/m2 iv x 4 days every 4 weeks and 11 with cis-DDP at a dose of 15 mg/m2 iv x 4 days combined with DTIC at a dose of 200 mg/m2 iv x 5 days every 4 weeks. Two of 21 patients (10%) showed a partial response to therapy. There were no complete responses and no apparent increases in length of survival for responders compared to nonresponders. One drug-related death occurred. Otherwise, drug toxicity was acceptable and appeared to be diminished by iv hydration and prolonged administration. In this study, cis-DDP was not effective for treatment of disseminated malignant melanoma.
21例播散性恶性黑色素瘤患者接受了顺式二氯二氨铂（II）（顺铂）治疗：10例单独使用顺铂，剂量为20mg/m²静脉注射，每4周连用4天；11例使用顺铂，剂量为15mg/m²静脉注射，每4周连用4天，并联合使用剂量为200mg/m²静脉注射、每4周连用5天的达卡巴嗪。21例患者中有2例（10%）对治疗有部分反应。没有完全缓解的病例，与无反应者相比，有反应者的生存期也没有明显延长。发生了1例与药物相关的死亡。除此之外，药物毒性是可以接受的，通过静脉补液和延长给药时间，毒性似乎有所减轻。在本研究中，顺铂对播散性恶性黑色素瘤的治疗无效。
