Becher R, Seeber S, Schmidt C G
J Cancer Res Clin Oncol. 1980;97(3):301-6. doi: 10.1007/BF00405782.
Twenty-five patients with measurable lesions of advanced malignant melanoma received a combined chemotherapy containing cis-dichlordiammineplatinum (II) (cisplatin) 30 mg daily at days 1, 3, 5, 7, 9, and ifosfamide 45 mg/kg at days 2, 4, 6, 8, and 10. Most of the patients had been previously treated with DTIC or DTIC-containing combinations. An objective response was observed in 10 patients including three complete and seven partial remissions. Medium survival was 3 months for nonresponders and 6 months for responders. Nausea and vomiting during chemotherapy could be reduced effectively be the use of levomepromacine (Neurocil). Hematologic toxicity was considerable in extensively pretreated patients and made it necessary to postpone subsequent courses in two cases.
25例晚期恶性黑色素瘤有可测量病灶的患者接受了联合化疗，其中顺二氯二氨铂（II）（顺铂）在第1、3、5、7、9天每日30mg，异环磷酰胺在第2、4、6、8、10天每日45mg/kg。大多数患者此前接受过达卡巴嗪或含达卡巴嗪的联合治疗。10例患者观察到客观缓解，包括3例完全缓解和7例部分缓解。无反应者的中位生存期为3个月，有反应者为6个月。化疗期间使用甲氧氯普胺（灭吐灵）可有效减轻恶心和呕吐。在接受过广泛预处理的患者中血液学毒性相当大，有2例因此不得不推迟后续疗程。
