确定亚种感染的新流行区域和风险因素：罗马尼亚农村地区的血清学调查。

Identifying New Areas of Endemicity and Risk Factors for subsp. Infection: Serosurvey in Rural Areas of Romania.

作者信息

Cheran Cristina Alexandra, Panciu Andreea Madalina, Riciu Claudia Doina, Nedelcu Iulia Maria, Iacob Diana Gabriela, Hristea Adriana

机构信息

Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Infectious Diseases, Bucharest Emergency Clinical Hospital, 014461 Bucharest, Romania.

出版信息

Pathogens. 2024 Sep 11;13(9):783. doi: 10.3390/pathogens13090783.

DOI:10.3390/pathogens13090783

PMID:39338974

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11434682/

Abstract

BACKGROUND

Mediterranean spotted fever (MSF) is an emerging tick-borne disease caused by subsp. primarily prevalent in Mediterranean and Southern Europe. We aimed to evaluate MSF seroprevalence and risk factors in non-endemic rural areas of Romania.

METHODS

We conducted a serosurvey in five counties not under MSF surveillance by testing 459 serum samples from adult volunteers for specific IgG antibodies using ELISA. Participants answered a questionnaire regarding demographics and MSF risk factors.

RESULTS

The median age of the participants was 60 years and 329 (71.7%) were female. Overall, 64 (13.9%) samples tested positive for IgG anti-, with rates ranging from 7.1% in Sibiu to 22.4% in Hunedoara. The median age of the positive individuals was 68 years, with a significantly higher seropositivity rate of 54.7% among those over 65 years ( = 0.01). Among those positive, 53 (82.8%) owned different household animals; 24 (37.5%) had daily contact with dogs, and 27 (42.2%) with livestock; 17 (26.6%) noted tick infestations of animals, and 23 (35.9%) reported tick bites.

CONCLUSIONS

This study revealed an important seroprevalence of MSF in Romanian areas considered non-endemic, indicating an expansion of its geographical range, probably due to climate change, and emphasizing the importance of enhanced surveillance and diagnostic capabilities nationwide.

摘要

背景

地中海斑疹热（MSF）是一种由[病原体亚种名称]引起的新发蜱传疾病，主要在地中海地区和南欧流行。我们旨在评估罗马尼亚非流行农村地区的地中海斑疹热血清阳性率及危险因素。

方法

我们在五个未受地中海斑疹热监测的县开展了一项血清学调查，通过酶联免疫吸附测定（ELISA）检测459名成年志愿者血清样本中的特异性IgG抗体。参与者回答了一份关于人口统计学和地中海斑疹热危险因素的问卷。

结果

参与者的年龄中位数为60岁，329名（71.7%）为女性。总体而言，64份（13.9%）样本的抗[病原体名称]IgG检测呈阳性，阳性率从锡比乌县的7.1%到胡内多阿拉县的22.4%不等。阳性个体的年龄中位数为68岁，65岁以上人群的血清阳性率显著更高，为54.7%（P = 0.01）。在阳性者中，53名（82.8%）拥有不同的家畜；24名（37.5%）每天与狗接触，27名（42.2%）与家畜接触；17名（26.6%）注意到家畜有蜱虫寄生，23名（35.9%）报告有蜱虫叮咬史。