Sanches Suellen Christtine da Costa, Ferreira Lindalva Maria de Meneses Costa, Pereira Rayanne Rocha, Lynch Desireé Gyles, Ramos Ingryd Nayara de Farias, Khayat André Salim, Carrera Silva-Júnior José Otávio, Rossi Alessandra, Ribeiro-Costa Roseane Maria
Laboratory of Pharmaceutical Nanotechnology, Faculty of Pharmaceutical Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Institute of Collective Health, Federal University of Western Para, Santarém 68135-110, Brazil.
Pharmaceutics. 2024 Sep 11;16(9):1195. doi: 10.3390/pharmaceutics16091195.
Organogels are semi-solid pharmaceutical forms whose dispersing phase is an organic liquid, for example, an oil, such as acai oil, immobilized by a three-dimensional network formed by the gelling agent. Organogels are being highlighted as innovative release systems for cosmetic active ingredients such as hyaluronic acid for topical applications. Acai oil was evaluated for its physicochemical parameters, fatty acid composition, lipid quality index, spectroscopic pattern (Attenuated total reflectance Fourier Transform Infrared Spectroscopy), thermal behavior, total phenolic, total flavonoids, and total carotenoids and β-carotene content. The effectiveness of the organogel incorporated with hyaluronic acid (OG + HA) was evaluated through ex vivo permeation and skin retention tests, in vitro tests by Attenuated total reflectance Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry. The physicochemical analyses highlighted that the acai oil exhibited quality standards in agreement with the regulatory bodies. Acai oil also showed high antioxidant capacity, which was correlated with the identified bioactive compounds. The cytotoxicity tests demonstrated that the formulation OG + HA does not release toxic substances into the biological environment that could impede cell growth, adhesion, and efficacy. In vitro and ex vivo analyses demonstrated that after 6 h of application, OG + HA presented a high level of hydration, thermal protection and release of HA. Thus, it can be concluded that the OG + HA formulation has the potential for physical-chemical applications, antioxidant quality, and potentially promising efficacy for application in the cosmetic areas.
有机凝胶是一种半固体制剂形式，其分散相为有机液体，例如油，如阿萨伊油，通过胶凝剂形成的三维网络固定。有机凝胶作为透明质酸等用于局部应用的化妆品活性成分的创新释放系统而受到关注。对阿萨伊油的物理化学参数、脂肪酸组成、脂质质量指数、光谱模式（衰减全反射傅里叶变换红外光谱）、热行为、总酚、总黄酮、总类胡萝卜素和β-胡萝卜素含量进行了评估。通过体外渗透和皮肤滞留试验、衰减全反射傅里叶变换红外光谱和差示扫描量热法进行的体外试验，评估了掺入透明质酸的有机凝胶（OG+HA）的有效性。物理化学分析表明，阿萨伊油的质量标准符合监管机构的要求。阿萨伊油还表现出较高的抗氧化能力，这与已鉴定的生物活性化合物相关。细胞毒性试验表明，OG+HA制剂不会向生物环境中释放可能阻碍细胞生长、粘附和功效的有毒物质。体外和离体分析表明，在应用6小时后，OG+HA表现出高水平的水合作用、热保护作用和透明质酸的释放。因此，可以得出结论，OG+HA制剂具有物理化学应用潜力、抗氧化质量，并且在化妆品领域应用可能具有良好的功效。
