Secobutanolides Isolated from Stem and Their Anti-Inflammatory Activity.

In this study, a new secobutanolide, named secosubamolide B (), along with three previously known secobutanolides (, , and ), were successfully isolated from a methanol extract of the stem of . The chemical structures of these compounds were elucidated through the analysis of spectroscopic data, and then compared with the existing literature to confirm their identities. Furthermore, the anti-inflammatory effect of these isolated compounds on bone marrow-derived dendritic cells stimulated by lipopolysaccharide (LPS) was evaluated. Compounds - showed the significant suppression of LPS-triggered IL-6 and IL-12 p40 production, with IC values between 1.8 and 24.1 µM. These findings may provide a scientific foundation for developing anti-inflammatory agents from .