醉香含笑茎木中的甾醇环氧化物、断丁内酯和丁内酯。

Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis.

作者信息

Cheng Ming-Jen, Tsai Ian-Lih, Lee Shoiw-Ju, Jayaprakasam Bolleddula, Chen Ih-Sheng

机构信息

Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.

出版信息

Phytochemistry. 2005 May;66(10):1180-5. doi: 10.1016/j.phytochem.2005.03.020.

DOI:10.1016/j.phytochem.2005.03.020

PMID:15924923

Abstract

A steryl epoxide, machillene (1), a secobutanolide, secomahubanolide (2), and two butanolides, zuihoenalide (3), and 3-(1-methoxyoctadecyl)-5-methylene-5H-furan-2-one (4), together with 12 known compounds, were isolated from stem wood of Machilus zuihoensis. Their structures were determined by means of spectroscopic analyses. Machillene (1) showed cytotoxic activity against NUGC-3 and HONE-1 cancer cell lines in vitro.

摘要

从醉香含笑的茎木中分离得到一种甾醇环氧化物——新含笑环氧物（1）、一种裂环丁内酯——裂环新含笑内酯（2）、两种丁内酯——醉香含笑内酯（3）和3-(1-甲氧基十八烷基)-5-亚甲基-5H-呋喃-2-酮（4），以及12种已知化合物。通过光谱分析确定了它们的结构。新含笑环氧物（1）在体外对NUGC-3和HONE-1癌细胞系显示出细胞毒性活性。