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膳食纤维的摄入量和类型与墨西哥溃疡性结肠炎(UC)患者的活动之间的相关性。

Correlation between the Quantity and Type of Dietary Fiber with the Activity in Mexican Patients with Ulcerative Colitis (UC).

机构信息

Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Ciudad de México 14080, Mexico.

Inflammatory Bowel Disease Clinic, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Vasco de Quiroga 15, Col. Belisario Domínguez Sección XVI, Alcaldía Tlalpan, Ciudad de México 14080, Mexico.

出版信息

Nutrients. 2024 Sep 21;16(18):3198. doi: 10.3390/nu16183198.

Abstract

: Ingestion of dietary fiber can influence in the remission of patients with ulcerative colitis (UC). There are no current recommendations for fiber intake in UC; therefore, we evaluate the association between dietary fiber and the activity of the disease. : Ours is a cross-sectional study in patients with a confirmed diagnosis of UC to whom a 24 h recall was applied; this allowed for the estimation and classification of type of dietary fiber. The patients were divided into two groups: (1) remission and (2) active UC. We analyzed the quantity and type of fiber with the grades of disease activity through Spearman correlation and logistic regression. : A total of 152 patients were included; it was found that those with clinically active UC consumed less total fiber ( = 0.016) and insoluble fiber ( = 0.018). Meanwhile, in endoscopic grade, the difference was for insoluble fiber ( = 0.038). Insoluble fiber had an inversely significant correlation with fecal calprotectin levels (r = -0.204; = 0.018). Logistic regression showed that less than 11 g of insoluble fiber was a risk factor for clinical activity (OR = 2.37; 95% CI 1.107-5.019; = 0.026). : Consumption below the current recommendation of total and insoluble dietary fiber is associated with clinical activity of UC.

摘要

膳食纤维的摄入可以影响溃疡性结肠炎(UC)患者的缓解。目前 UC 患者没有膳食纤维摄入量的建议,因此,我们评估了膳食纤维与疾病活动之间的关系。

我们对确诊为 UC 的患者进行了一项横断面研究,对患者进行了 24 小时回忆,以估计和分类膳食纤维的类型。患者分为两组:(1)缓解期和(2)活动期 UC。我们通过 Spearman 相关分析和逻辑回归分析了疾病活动的纤维数量和类型。

共纳入 152 例患者,发现临床活动期 UC 患者总膳食纤维( = 0.016)和不溶性膳食纤维( = 0.018)摄入量较少。同时,在内镜分级中,不溶性纤维的差异有统计学意义( = 0.038)。不溶性纤维与粪便钙卫蛋白水平呈显著负相关(r = -0.204; = 0.018)。逻辑回归显示,不溶性膳食纤维摄入量小于 11g 是临床活动的危险因素(OR = 2.37;95%CI 1.107-5.019; = 0.026)。

低于当前膳食纤维总摄入量和不溶性膳食纤维推荐量与 UC 的临床活动有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcca/11435422/176ef964c52f/nutrients-16-03198-g001.jpg

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