Guerrero-Munoz F, de Lourdes Guerrero M, Way E L, Li C H
Science. 1979 Oct 5;206(4414):89-91. doi: 10.1126/science.39340.
The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.
10⁻⁹M浓度的β-内啡肽在体外可抑制从小鼠大脑中提取的神经末梢部分对⁴⁵Ca²⁺的摄取，并且在向小鼠脑室内注射7皮摩尔β-内啡肽后也会出现这种抑制现象。通过使用阿片拮抗剂纳洛酮逆转了该作用，从而证明这种作用是β-内啡肽的特异性阿片激动剂反应。应考虑β-内啡肽在调节钙通量和神经递质释放中的作用。
