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蟾蜍视杆细胞的明适应机制。

Mechanisms of light adaptation in toad rods.

作者信息

Cervetto L, Torre V, Rispoli G, Marroni P

出版信息

Exp Biol. 1985;44(3):147-57.

PMID:3934000
Abstract

A steady illumination equivalent to about 1000 or more photoisomerizations per s per rod completely abolishes the dark current and induces a total desensitization of toad rods. Under these conditions, however, both current and sensitivity recover from the initial suppression and reach a new steady level within about 30 s. Both extent and time course of recovery depend on the intensity of the conditioning light. The ability of rods to respond to light stimuli under light saturating conditions is enhanced by procedures aimed at increasing the sodium gradient across their surface membrane. The results suggest that rods can also contribute significantly to vision at photopic levels of ambient light. The mechanisms underlying this adaptational property of rods are discussed.

摘要

相当于每根视杆每秒约1000次或更多次光异构化的稳定光照会完全消除暗电流,并使蟾蜍视杆产生完全脱敏。然而,在这些条件下,电流和敏感度都会从最初的抑制状态恢复,并在约30秒内达到新的稳定水平。恢复的程度和时间进程取决于调节光的强度。通过旨在增加视杆表面膜上钠梯度的程序,可以增强视杆在光饱和条件下对光刺激的响应能力。结果表明,在环境光的明视觉水平下,视杆对视也有显著贡献。文中讨论了视杆这种适应性特性背后的机制。

相似文献

1
Mechanisms of light adaptation in toad rods.蟾蜍视杆细胞的明适应机制。
Exp Biol. 1985;44(3):147-57.
2
Calcium and light adaptation in retinal rods and cones.视网膜视杆细胞和视锥细胞中的钙与光适应
Nature. 1988 Jul 7;334(6177):69-71. doi: 10.1038/334069a0.
3
The sodium current underlying the responses of toad rods to light.蟾蜍视杆细胞对光反应的钠电流
J Physiol. 1981 Aug;317:223-42. doi: 10.1113/jphysiol.1981.sp013822.
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The effect of phosphodiesterase inhibitors on the electrical activity of toad rods.磷酸二酯酶抑制剂对蟾蜍视杆细胞电活动的影响。
J Physiol. 1983 Oct;343:277-94. doi: 10.1113/jphysiol.1983.sp014892.
5
Transduction of light energy to electrical signals in photoreceptor cells.
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Evidence for a disk-membrane conductance increase on illumination of rod outer segments.视杆细胞外段受光照时盘膜电导增加的证据。
J Physiol. 1972 Jul;224(2):69P-71P.
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Step response of mouse rod photoreceptors modeled in terms of elemental photic signals.
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The relation between excitation and adaptation within the rod's outer segment.视杆细胞外段内兴奋与适应之间的关系。
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Dark adaptation in vertebrate photoreceptors.脊椎动物光感受器中的暗适应。
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Light-induced resistance changes in retinal rods and cones of the tiger salamander.虎螈视网膜视杆细胞和视锥细胞中光诱导的电阻变化。
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引用本文的文献

1
Effect of blocking the Na+/K+ ATPase on Ca2+ extrusion and light adaptation in mammalian retinal rods.阻断钠钾ATP酶对哺乳动物视网膜视杆细胞钙外流和光适应的影响。
Biophys J. 1995 Aug;69(2):439-50. doi: 10.1016/S0006-3495(95)79917-9.
2
Ion transport by the Na-Ca exchange in isolated rod outer segments.分离的视杆细胞外段中钠钙交换介导的离子转运。
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4548-52. doi: 10.1073/pnas.85.12.4548.
3
Role of calcium in regulating the cyclic GMP cascade of phototransduction in retinal rods.钙在调节视网膜视杆细胞光转导的环鸟苷酸级联反应中的作用。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7109-13. doi: 10.1073/pnas.83.18.7109.
4
Kinetics of phototransduction in retinal rods of the newt Triturus cristatus.蝾螈(Triturus cristatus)视网膜视杆细胞中光转导的动力学
J Physiol. 1989 Dec;419:265-95. doi: 10.1113/jphysiol.1989.sp017873.
5
Calcium homeostasis in the outer segments of retinal rods from the tiger salamander.虎螈视网膜视杆细胞外段的钙稳态
J Physiol. 1992 Sep;455:111-42. doi: 10.1113/jphysiol.1992.sp019293.