van den Bogert C, Holtrop M, de Vries H, Kroon A M
FEBS Lett. 1985 Nov 18;192(2):225-9. doi: 10.1016/0014-5793(85)80112-5.
Specific inhibition of mitochondrial protein synthesis reduces the oxidation rate of NADH-linked substrates in rat liver as well as in Neurospora crassa mitochondria. The present study shows that this is due to the fact that inhibition of mitochondrial protein synthesis leads to a decrease of the concentration of active complex I. Therefore, these results demonstrate that at least one of the genes for the subunits of complex I is localized on mitochondrial DNA.
特异性抑制线粒体蛋白质合成会降低大鼠肝脏以及粗糙脉孢菌线粒体中与NADH相关底物的氧化速率。本研究表明，这是因为抑制线粒体蛋白质合成会导致活性复合物I的浓度降低。因此，这些结果证明复合物I亚基的基因中至少有一个位于线粒体DNA上。
