Gerin Larissa, Pedroso Andrey Oeiras, Antonini Marcela, Gir Elucir, Spire Bruno, Reis Renata Karina
Epidemiological Surveillance Office at Ribeirão Preto Municipal Health Department, Ribeirão Preto 14015100, São Paulo, Brazil.
Ribeirão Preto College of Nursing, University of São Paulo, Ribeirão Preto 14040902, São Paulo, Brazil.
Vaccines (Basel). 2024 Sep 1;12(9):1003. doi: 10.3390/vaccines12091003.
People living with HIV (PLHIV) are at greater risk of illness and death from vaccine-preventable diseases. This study aimed to identify the predictors associated with the recommended vaccination schedule for this group. This was a single-center cross-sectional study conducted in a large Brazilian municipality, evaluating the vaccination statuses of 645 PLHIV for nine immunizers. The primary outcome was the adequacy of the vaccination schedule. The vaccination status was assessed for the diphtheria/tetanus, hepatitis B, hepatitis A, measles/mumps/rubella, yellow fever, 13- and 23-valent pneumococcal, meningococcal C, and HPV vaccines. Those who had received all of the recommended vaccinations in accordance with the schedule established by the government at the time of the assessment, without any delays, were classified as having received an "adequate schedule". The independent variables included sociodemographic, clinical-epidemiological, and social vulnerability factors, analyzed by multiple logistic regression with adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). Only 47 individuals (7.3%) had an adequate vaccination schedule for all vaccines. The vaccines with the highest adequacy rate were diphtheria and tetanus (533; 82.6%), and the one with the lowest rate was measles/mumps/rubella (MMR) (243; 37.7%). The main predictors of a complete vaccination schedule were the age group, place of clinical follow-up, and where they received their last doses of vaccines. Educational interventions for PLHIV and health professionals are needed to improve the vaccination coverage in this group.
感染艾滋病毒的人(PLHIV)因疫苗可预防疾病而患病和死亡的风险更高。本研究旨在确定与该群体推荐疫苗接种计划相关的预测因素。这是一项在巴西一个大型城市进行的单中心横断面研究,评估了645名PLHIV针对九种疫苗的接种状况。主要结果是疫苗接种计划的充分性。对接种白喉/破伤风、乙型肝炎、甲型肝炎、麻疹/腮腺炎/风疹、黄热病、13价和23价肺炎球菌、C群脑膜炎球菌和人乳头瘤病毒疫苗的状况进行了评估。那些在评估时按照政府制定的时间表接受了所有推荐疫苗接种且无任何延迟的人被归类为接受了“充分接种计划”。自变量包括社会人口统计学、临床流行病学和社会脆弱性因素,通过多因素逻辑回归分析,得出调整后的比值比(OR)和95%置信区间(95%CI)。只有47人(7.3%)所有疫苗的接种计划充分。接种率最高的疫苗是白喉和破伤风(533人;82.6%),接种率最低的是麻疹/腮腺炎/风疹(MMR)(243人;37.7%)。完整接种计划的主要预测因素是年龄组、临床随访地点以及他们最后一剂疫苗的接种地点。需要对PLHIV和卫生专业人员进行教育干预,以提高该群体的疫苗接种覆盖率。