Wu Pei-Wen, Chin Yu-Ting, Lin Wei-Ting, Tsai Sharon, Lee Chun-Ying, Tsai Wei-Chung, Seal David W, Lee Chien-Hung
Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Social, Behavioral, and Population Sciences, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Pediatr Obes. 2025 Jan;20(1):e13176. doi: 10.1111/ijpo.13176. Epub 2024 Sep 28.
Uric acid (UA) and homeostatic model assessment of insulin resistance (HOMA-IR) are endogenous biomarkers implicated in metabolic disorders and dysfunction.
To investigate the structural associations between sugar-sweetened beverage intake (SSB), UA, HOMA-IR and adolescent latent MetS construct (MetsC) representing paediatric metabolic syndrome (MetS).
A population-based representative adolescent cohort (n = 1454) was evaluated for risk profiles of MetS. Structural equation modelling was performed to identify multifactor structural associations between study parameters and evaluate mediating effects.
Adolescents had a single-factor latent construct representing MetS. Increased SSB intake was associated with higher UA and HOMA-IR levels, and the two biomarkers were positively associated with the MetsC score. UA and HOMA-IR exerted three mediating effects on the association between fructose-rich tea beverage (FTB) intake of >500 mL/day and MetsC: adjusted standardized coefficient and mediating effect (%), FTB → UA → MetsC: 0.071, 23.1%; FTB → HOMA-IR → MetsC: 0.034, 11.0%; FTB → UA → HOMA-IR → MetsC: 0.010, 3.1%. The UA-associated pathways accounted for 31.1% of the overall mediation on the association between bottled sugar-containing beverage intake and MetsC. After accounting for the UA- and HOMA-IR-derived detrimental effects, the fructose-rich tea beverage intake of >500 mL/day had a tea-related beneficial effect on MetsC, with an adjusted standardized coefficient of -0.103.
UA and HOMA-IR individually and jointly mediate the adverse effects of high fructose-rich SSB intake on the mechanisms underlying paediatric MetS. Fructose-free tea-based beverages may have a beneficial effect on latent MetS structure in adolescents.
尿酸（UA）和胰岛素抵抗的稳态模型评估（HOMA-IR）是与代谢紊乱和功能障碍相关的内源性生物标志物。
研究含糖饮料摄入量（SSB）、UA、HOMA-IR与代表儿童代谢综合征（MetS）的青少年潜在MetS结构（MetsC）之间的结构关联。
对一个基于人群的代表性青少年队列（n = 1454）进行MetS风险评估。采用结构方程模型确定研究参数之间的多因素结构关联，并评估中介效应。
青少年有一个代表MetS的单因素潜在结构。SSB摄入量增加与更高的UA和HOMA-IR水平相关，这两种生物标志物与MetsC评分呈正相关。UA和HOMA-IR对每天果糖丰富的茶饮料（FTB）摄入量>500 mL与MetsC之间的关联产生三种中介效应：调整后的标准化系数和中介效应（%），FTB→UA→MetsC：0.071，23.1%；FTB→HOMA-IR→MetsC：0.034，11.0%；FTB→UA→HOMA-IR→MetsC：0.010，3.1%。与UA相关的途径占瓶装含糖饮料摄入量与MetsC之间总体中介作用的31.1%。在考虑了UA和HOMA-IR产生的有害影响后，每天果糖丰富的茶饮料摄入量>500 mL对MetsC有与茶相关的有益作用，调整后的标准化系数为-0.103。
UA和HOMA-IR分别和共同介导了高果糖丰富的SSB摄入量对儿童MetS潜在机制的不利影响。不含果糖的茶基饮料可能对青少年潜在的MetS结构有有益作用。
