Yang Tzong-Hann, Cheng Yen-Fu, Lin Herng-Ching, Chen Chin-Shyan
Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.
Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei, Taiwan.
J Periodontol. 2025 Apr;96(4):383-389. doi: 10.1002/JPER.24-0311. Epub 2024 Sep 28.
Emerging concerns link periodontitis to an array of cancers, notably thyroid cancer, though investigations into these associations are still in the nascent stages. This population-based study aimed to investigate the association of thyroid cancer with chronic periodontitis using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010).
This case-control study utilized LHID2010, selecting 2,775 patients diagnosed with thyroid cancer, matched with 8,325 controls based on age, sex, income, and the presence of diabetes, hypertension, hyperlipidemia, human papillomavirus infection, and tobacco use disorder using propensity-score matching. Multivariate logistic regression models were used to evaluate the association of thyroid cancer with chronic periodontitis.
A chi-squared analysis demonstrated a significant disparity in the prevalence of chronic periodontitis between those diagnosed with thyroid cancer and the controls, with prevalence rates of 38.5% and 24.1% respectively, and a p-value less than 0.001. The odds ratio (OR) for having prior chronic periodontitis among patients with thyroid cancer compared to controls was 1.991, with a 95% confidence interval (CI) of 1.816-2.184 and a p-value less than 0.001. The association was similar between sexes, yielding adjusted ORs of 1.991 (95% CI = 1.816∼2.184) for men and 1.962 (95% CI = 1.765-2.182) for women, indicating a statistically significant higher prevalence of chronic periodontitis in both male and female patients diagnosed with thyroid cancer compared to their control counterparts.
The findings highlight chronic periodontitis as a potential risk factor for thyroid cancer, underscoring the importance of integrated health surveillance and preventive strategies that encompass oral health.
This study aimed to explore the link between thyroid cancer and chronic periodontitis. Using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010), we selected 2,775 patients with thyroid cancer and matched them with 8,325 individuals without the disease based on age, sex, income, and other health conditions such as diabetes, hypertension, high cholesterol, HPV infection, and smoking habits. The study used statistical models to examine the relationship between thyroid cancer and chronic periodontitis. The findings showed that 38.5% of thyroid cancer patients had chronic periodontitis, compared to 24.1% of the control group. The odds of having chronic periodontitis were nearly twice as high in thyroid cancer patients. This pattern was consistent for both men and women. The study underscores the strong connection between chronic periodontitis and thyroid cancer, emphasizing the importance of raising public awareness about the potential risks of periodontitis.
越来越多的担忧将牙周炎与一系列癌症联系起来，尤其是甲状腺癌，不过对这些关联的研究仍处于初期阶段。这项基于人群的研究旨在利用台湾2010年纵向健康保险数据库（LHID2010）调查甲状腺癌与慢性牙周炎之间的关联。
这项病例对照研究使用了LHID2010，选取2775例被诊断为甲状腺癌的患者，基于年龄、性别、收入以及是否患有糖尿病、高血压、高脂血症、人乳头瘤病毒感染和烟草使用障碍，采用倾向得分匹配法与8325名对照进行匹配。使用多变量逻辑回归模型评估甲状腺癌与慢性牙周炎之间的关联。
卡方分析表明，被诊断为甲状腺癌的患者与对照组之间慢性牙周炎患病率存在显著差异，患病率分别为38.5%和24.1%，p值小于0.001。与对照组相比，甲状腺癌患者既往患有慢性牙周炎的比值比（OR）为1.991，95%置信区间（CI）为1.816 - 2.184，p值小于0.001。两性之间的关联相似，男性调整后的OR为1.991（95%CI = 1.816∼2.184），女性为1.962（95%CI = 1.765 - 2.182），表明与对照相比，被诊断为甲状腺癌的男性和女性患者慢性牙周炎患病率在统计学上均显著更高。
研究结果突出了慢性牙周炎作为甲状腺癌潜在危险因素的作用，强调了涵盖口腔健康的综合健康监测和预防策略的重要性。
本研究旨在探索甲状腺癌与慢性牙周炎之间的联系。利用台湾2010年纵向健康保险数据库（LHID2010），我们选取了2775例甲状腺癌患者，并根据年龄、性别、收入以及糖尿病、高血压、高胆固醇、人乳头瘤病毒感染和吸烟习惯等其他健康状况，将他们与8325名未患该疾病的个体进行匹配。该研究使用统计模型来检验甲状腺癌与慢性牙周炎之间的关系。研究结果显示，38.5%的甲状腺癌患者患有慢性牙周炎，而对照组这一比例为24.1%。甲状腺癌患者患慢性牙周炎的几率几乎是对照组患者的两倍。这种模式在男性和女性中均一致。该研究强调了慢性牙周炎与甲状腺癌之间的紧密联系，凸显了提高公众对牙周炎潜在风险认识的重要性。
