Department of Exercise Physiology, Ilam Branch, Islamic Azad University, Ilam, Iran.
Comparative Anatomy and Embryology, Department of Histology, Faculty of Veterinary Sciences, Ilam University, Ilam, Iran.
Metab Brain Dis. 2024 Oct;39(7):1283-1290. doi: 10.1007/s11011-024-01377-w. Epub 2024 Sep 28.
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that led to brain atrophy. The purpose of this study was to investigate the effects of pre-and post-conditioning with exercise on demyelination and brain morphology. Thirty male rats were randomly divided into five groups (n = 6 per group), consisting of a healthy control group (Control), an MS group, and three exercise groups: the group that performed the exercise protocol (running on a treadmill 5 days/week for 6 weeks) before the MS induction (EX + MS), the group that performed the exercise protocol during the MS induction (MS + EX), and the group that performed the exercise protocol before and during the MS induction (EX + MS + EX). The expression of Myelin basic protein (MBP), and demyelination in the corpus callosum and the volume, weight, length, width, and height of the brain were measured. The EX + MS + EX showed a significant increase in the expression of MBP compared to other MS groups (**p < 0.01) as well as a significant decrease in the area of demyelination of the corpus callosum compared to MS and MS + EX groups (**p < 0.01). However, there were no significant differences between the MS group and exercised groups for brain morphology. The exercise showed neuroprotective effects, as evidenced by decreased areas of demyelination and improved MBP expression.
多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性脱髓鞘疾病，可导致脑萎缩。本研究旨在探讨预先和后适应运动对脱髓鞘和脑形态的影响。30 只雄性大鼠随机分为五组（每组 n = 6），包括健康对照组（Control）、MS 组和三组运动组：MS 诱导前进行运动方案（每周 5 天在跑步机上跑步 6 周）的组（EX + MS）、在 MS 诱导期间进行运动方案的组（MS + EX）和在 MS 诱导前后进行运动方案的组（EX + MS + EX）。测量髓鞘碱性蛋白（MBP）的表达以及胼胝体的脱髓鞘情况以及大脑的体积、重量、长度、宽度和高度。与其他 MS 组相比，EX + MS + EX 组的 MBP 表达显著增加（**p < 0.01），与 MS 组和 MS + EX 组相比，胼胝体脱髓鞘面积显著减少（**p < 0.01）。然而，MS 组和运动组之间在脑形态学方面没有显著差异。运动表现出神经保护作用，这表现为脱髓鞘面积减少和 MBP 表达改善。
