Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
Bull Exp Biol Med. 2024 Sep;177(5):653-657. doi: 10.1007/s10517-024-06243-4. Epub 2024 Sep 28.
The polymorphism of HLA class II genes was studied in COVID-19 survivors and vaccinated people. Six allelic variants of DQA1, 10 of DQB1, and 11 of DRB1 were identified. The DQA105:01 allele predominated in vaccinated volunteers and the DQA102:01, 01:03, and DQB106:02-8 alleles predominated in convalescents. In the groups with DQA1*01:01, 05:01 and 06:01 alleles, a high proportion of individuals seropositive for SARS-CoV-2 S protein was found. In the group with DQA102:01 allele, 40% of volunteers were found to have IgM and a significantly lower quantity of IgG to N protein of coronavirus. Comparative analysis showed a statistically significant increase in IL-10 levels in carriers of the DQA101:01 allele, which may indicate the influence of this allele on cytokine production. Further study of the immune response indices and their association with HLA class II gene polymorphism will provide better understanding of the mechanisms of COVID-19 immunogenesis.
研究了 COVID-19 幸存者和接种疫苗人群中人类白细胞抗原（HLA）II 类基因的多态性。鉴定了 DQA1 的 6 个等位基因变异体，DQB1 的 10 个等位基因变异体和 DRB1 的 11 个等位基因变异体。在接种疫苗的志愿者中，DQA105:01 等位基因占优势，而在康复者中，DQA102:01、01:03 和 DQB106:02-8 等位基因占优势。在具有 DQA1*01:01、05:01 和 06:01 等位基因的组中，发现了大量 SARS-CoV-2 S 蛋白血清阳性的个体。在具有 DQA102:01 等位基因的组中，发现 40%的志愿者具有 IgM，冠状病毒 N 蛋白的 IgG 量明显较低。比较分析表明，DQA101:01 等位基因携带者的 IL-10 水平显著升高，这可能表明该等位基因对细胞因子产生的影响。进一步研究免疫反应指标及其与 HLA II 类基因多态性的关系，将有助于更好地了解 COVID-19 免疫发生的机制。
