Department of Respiratory Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Immun Inflamm Dis. 2020 Dec;8(4):684-694. doi: 10.1002/iid3.358. Epub 2020 Oct 13.
The emergence of SARS-CoV-2 has caused global public health and economic crisis. Human leukocyte antigen (HLA) is a critical component of the viral antigen presentation pathway and plays essential roles in conferring differential viral susceptibility and severity of diseases. However, the association between HLA gene polymorphisms and risk for COVID-19 has not been fully elucidated. We hypothesized that HLA genotypes might impact on the differences in morbidity and mortality of COVID-19 across countries.
We conducted in silico analyses and examined an association of HLA gene polymorphisms with prevalence and mortality of COVID-19 by using publicly available databases.
We found that a possible association between HLA-A02:01 and an increased risk for COVID-19. HLA-A02:01 had a relatively lower capacity to present SARS-CoV-2 antigens compared with other frequent HLA class I molecules, HLA-A11:01 or HLA-A24:02.
This study suggests that individuals with HLA-A11:01 or HLA-A24:02 genotypes may generate efficiently T-cell-mediated antiviral responses to SARS-CoV-2 compared with HLA-A*02:01. The differences in HLA genotypes may potentially alter the course of the disease and its transmission.
SARS-CoV-2 的出现引发了全球公共卫生和经济危机。人类白细胞抗原 (HLA) 是病毒抗原呈递途径的关键组成部分，在赋予病毒易感性和疾病严重程度的差异方面发挥着重要作用。然而，HLA 基因多态性与 COVID-19 风险之间的关联尚未完全阐明。我们假设 HLA 基因型可能会影响 COVID-19 在各国的发病率和死亡率的差异。
我们进行了计算机模拟分析，并使用公开可用的数据库研究了 HLA 基因多态性与 COVID-19 的患病率和死亡率之间的关联。
我们发现 HLA-A02:01 与 COVID-19 风险增加之间可能存在关联。与其他常见的 HLA I 类分子 HLA-A11:01 或 HLA-A24:02 相比，HLA-A02:01 呈现 SARS-CoV-2 抗原的能力相对较低。
这项研究表明，与 HLA-A02:01 相比，具有 HLA-A11:01 或 HLA-A*24:02 基因型的个体可能会产生针对 SARS-CoV-2 的高效 T 细胞介导的抗病毒反应。HLA 基因型的差异可能会改变疾病的进程及其传播。
