用髓磷脂喂养愤怒。
Feeding the wrath with myelin.
机构信息
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Trends Immunol. 2024 Oct;45(10):729-731. doi: 10.1016/j.it.2024.09.004. Epub 2024 Sep 27.
Abstract
Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.
摘要
克洛斯特曼及其同事研究了胶质母细胞瘤的分子亚型在放射治疗和疾病复发过程中的分子和细胞变化。他们在神经前体细胞/少突胶质祖细胞样到间充质样转化过程中发现了一种独特的免疫-癌细胞代谢串扰，其中巨噬细胞以富含胆固醇的髓磷脂碎片为食，为间充质肿瘤细胞提供脂质，从而促进胶质母细胞瘤的生长。
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本文引用的文献
1
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Cell. 2024 Sep 19;187(19):5336-5356.e30. doi: 10.1016/j.cell.2024.07.030. Epub 2024 Aug 12.
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Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma.新辅助 PD-1 阻断诱导 T 细胞和 cDC1 激活，但未能克服复发性胶质母细胞瘤中免疫抑制性肿瘤相关巨噬细胞。
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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.新辅助抗 PD-1 免疫治疗在复发性胶质母细胞瘤中促进了肿瘤内和全身免疫应答，并带来生存获益。
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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.原发性和治疗后胶质母细胞瘤的全基因组和多区域外显子组测序揭示了肿瘤进化模式。
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