Tian Yuan, Wang Xiaowei, Wu Cong, Qiao Jiaming, Jin Hai, Li Huafei
School of Lifesciences, Shanghai University, 333 Nanchen Road, Shanghai, 200444, P.R. China.
Department of Thoracic Surgery/Clinical Research Center, The First Affiliated Hospital of Navy Medical University, 168 Changhai Road, Shanghai, 200433, P.R. China.
Cancer Cell Int. 2024 Sep 28;24(1):326. doi: 10.1186/s12935-024-03510-2.
Currently, even the most effective anti-cancer therapies are often limited by the development of drug resistance and tumor relapse, which is a major challenge facing current cancer research. A deep understanding of the molecular and biochemical bases of drug efficacy that can help predict the clinical drug resistance, coupled with the evolution of systematic genomic and proteomic technologies, have facilitated studies identifying and elucidating the underlying mechanisms. In this review, we focus on several important issues on cancer drug resistance and provide a framework for understanding the common ways by which cancers develop resistance to therapeutic agents. With the increasing arsenal of novel anticancer agents and techniques, there are now unprecedented opportunities to understand and overcome drug resistance. The proteolysis targeting chimera (PROTAC) technology, immunotherapy, nanomedicine, and real-time monitoring of drug response all provide effective approaches for combating drug resistance. In addition to the advancement of therapeutic technologies, the revolution of treatment concept is also of great importance. We can take advantage of the interplay between drug sensitive and resistant subclones for combating cancer. However, there remains a long way to go in the protracted war against cancer drug resistance.
目前，即使是最有效的抗癌疗法也常常受到耐药性发展和肿瘤复发的限制，这是当前癌症研究面临的一项重大挑战。深入了解有助于预测临床耐药性的药物疗效的分子和生化基础，再加上系统基因组学和蛋白质组学技术的发展，推动了对潜在机制的识别和阐释研究。在这篇综述中，我们聚焦于癌症耐药性的几个重要问题，并提供一个框架来理解癌症对治疗药物产生耐药性的常见方式。随着新型抗癌药物和技术的不断增加，现在有前所未有的机会来理解和克服耐药性。蛋白酶靶向嵌合体（PROTAC）技术、免疫疗法、纳米医学以及药物反应的实时监测都为对抗耐药性提供了有效的方法。除了治疗技术的进步，治疗理念的变革也至关重要。我们可以利用药物敏感和耐药亚克隆之间的相互作用来对抗癌症。然而，在与癌症耐药性的持久战中，仍有很长的路要走。
