淋巴瘤治疗后年轻男性和女性的生育能力：一项人群研究。
Fertility in young men and women after treatment for lymphoma: a study of a population.
作者信息
King D J, Ratcliffe M A, Dawson A A, Bennett B, Macgregor J E, Klopper A I
出版信息
J Clin Pathol. 1985 Nov;38(11):1247-51. doi: 10.1136/jcp.38.11.1247.
Abstract
All young patients in the Grampian area attending the lymphoma review clinic who had received first line treatment for Hodgkin's disease and had attained complete remission without subsequent relapse were studied between 1980 and 1983. Chemotherapy with MVPP (mustine, vinblastine, procarbazine, and prednisolone) had more severe effects on the fertility of men than that of women; younger women and those taking oral contraceptives were more likely to retain fertility than those over 30 or not taking the pill at the time of chemotherapy, but these two effects could not be differentiated. Premature menopause was common after treatment with MVPP. Mantle radiotherapy had no discernible effect on gonadal function.
摘要
1980年至1983年间，对格兰扁地区淋巴瘤复查门诊中所有接受过霍奇金病一线治疗且已完全缓解且无后续复发的年轻患者进行了研究。MVPP（氮芥、长春花碱、丙卡巴肼和泼尼松龙）化疗对男性生育能力的影响比对女性更严重；年轻女性以及当时服用口服避孕药的女性比30岁以上或化疗时未服用避孕药的女性更有可能保留生育能力，但这两种影响无法区分。MVPP治疗后过早绝经很常见。斗篷式放疗对性腺功能没有明显影响。
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