Huveneers Stephan, Phng Li-Kun
Amsterdam UMC, Location University of Amsterdam, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.
Laboratory for Vascular Morphogenesis, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Curr Opin Cell Biol. 2024 Dec;91:102441. doi: 10.1016/j.ceb.2024.102441. Epub 2024 Sep 28.
The efficient distribution of oxygen and metabolites is critical for embryonic development and growth as well as tissue homeostasis. This is achieved by endothelial cells forming and maintaining a closed, circulatory network of tubular blood vessels. Endothelial cells are highly plastic cells with the capability to generate diverse dynamic responses at different stages of vessel development in order to build vessel networks of tissue-specific patterns and morphologies. In this review, we discuss new conceptual advances gained from in vitro and in vivo models of angiogenesis on the control of endothelial cell dynamics. We highlight the complex interplay between mechanical cues, actin cytoskeleton and endothelial behaviors, and the emerging importance of hydrostatic pressure in complementing actin-dependent mechanisms to regulate endothelial cell mechanics and angiogenesis. Understanding these processes provides insights into vascular repair and regeneration mechanisms.
氧气和代谢产物的有效分配对于胚胎发育、生长以及组织稳态至关重要。这是通过内皮细胞形成并维持一个封闭的管状血管循环网络来实现的。内皮细胞是高度可塑性的细胞，能够在血管发育的不同阶段产生多种动态反应，以构建具有组织特异性模式和形态的血管网络。在本综述中，我们讨论了从血管生成的体外和体内模型中获得的关于内皮细胞动力学控制的新的概念性进展。我们强调了机械信号、肌动蛋白细胞骨架与内皮细胞行为之间的复杂相互作用，以及流体静压在补充肌动蛋白依赖性机制以调节内皮细胞力学和血管生成方面新出现的重要性。了解这些过程有助于深入了解血管修复和再生机制。
