Zapata-Linares Natalia, Loisay Léa, de Haro Diego, Berenbaum Francis, Hügle Thomas, Geurts Jeroen, Houard Xavier
Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), F-75012, Paris, France.
Service of Rheumatology, Department of Musculoskeletal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Biochimie. 2024 Dec;227(Pt B):130-138. doi: 10.1016/j.biochi.2024.09.015. Epub 2024 Sep 27.
Osteoarthritis (OA) is a major disease whose prevalence increases with aging, sedentary lifestyles, and obesity. The association between obesity and OA has been well documented, but the precise mechanisms underlying this heightened risk remain unclear. While obesity imposes greater forces on joints, systemic fat-derived factors such as lipids or adipokine may potentially act on the pathophysiology of OA, but the exact role of these factors in weight-bearing and non-weight-bearing joints remains elusive. Intra-articular adipose tissues (IAAT) have gained significant attention for actively participating in OA pathogenesis by interacting with various joint tissues. Lipid content has been proposed as a diagnostic target for early OA detection and a potential source of biomarkers. Moreover, targeting a specific IAAT called infrapatellar fat pad (IFP) and its lipids hold promise for attenuating OA-associated inflammation. Conversely, bone marrow adipose tissue (BMAT), which was long thought to be an inert filling tissue, is now increasingly considered a dynamic tissue whose volume and lipid content regulate bone remodeling in pathological conditions. Given OA's ability to alter adipose tissues, particularly those within the joint (IFP and BMAT), and the influence of adipose tissues on OA pathogenesis, this review examines the lipids produced by OA-associated adipose tissues, shedding light on their potential role in OA pathophysiology and highlighting them as potential therapeutic targets.
骨关节炎（OA）是一种主要疾病，其患病率随着衰老、久坐的生活方式和肥胖而增加。肥胖与OA之间的关联已有充分记录，但这种风险增加背后的确切机制仍不清楚。虽然肥胖会给关节施加更大的压力，但全身性脂肪衍生因子，如脂质或脂肪因子，可能会对OA的病理生理学产生影响，但其在负重和非负重关节中的确切作用仍然难以捉摸。关节内脂肪组织（IAAT）通过与各种关节组织相互作用积极参与OA发病机制，已受到广泛关注。脂质含量已被提议作为早期OA检测的诊断靶点和生物标志物的潜在来源。此外，针对一种名为髌下脂肪垫（IFP）的特定IAAT及其脂质有望减轻OA相关炎症。相反，长期以来被认为是一种惰性填充组织的骨髓脂肪组织（BMAT），现在越来越被视为一种动态组织，其体积和脂质含量在病理条件下调节骨重塑。鉴于OA改变脂肪组织的能力，特别是关节内的脂肪组织（IFP和BMAT），以及脂肪组织对OA发病机制的影响，本综述研究了OA相关脂肪组织产生的脂质，揭示它们在OA病理生理学中的潜在作用，并将它们作为潜在的治疗靶点加以强调。
