Yuan Xiqian, Hu Siyuan, Fan Xiaochong, Jiang Chao, Xu Yan, Hao Ruochen, Xu Zili, Yu Yiyang, Rastegar-Kashkooli Yousef, Huang Leo, Wang Tom J, Wang Qiao, Su Songxue, Wang Limin, Wang Junyang, Wang Menglu, Kim Yun Tai, Bhawal Ujjal K, Wang Fushun, Zhao Ting, Wang Junmin, Chen Xuemei, Wang Jian
Department of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Stroke Vasc Neurol. 2025 Jun 30;10(3):391-406. doi: 10.1136/svn-2024-003418.
Central poststroke pain (CPSP) is a medical complication that arises poststroke and significantly impacts the quality of life and social functioning of affected individuals. Despite ongoing research, the exact pathomechanisms of CPSP remain unclear, and practical treatments are still unavailable. Our review aims to systematically analyse current clinical and preclinical studies on CPSP, which is critical for identifying gaps in knowledge and guiding the development of effective therapies. The review will clarify the clinical characteristics, evaluation scales and contemporary therapeutic approaches for CPSP based on clinical investigations. It will particularly emphasise the CPSP model initiated by stroke, shedding light on its underlying mechanisms and evaluating treatments validated in preclinical studies. Furthermore, the review will not only highlight methodological limitations in animal trials but also offer specific recommendations to researchers to improve the quality of future investigations and guide the development of effective therapies. This review is expected to provide valuable insights into the current knowledge regarding CPSP and can serve as a guide for future research and clinical practice. The review will contribute to the scientific understanding of CPSP and help develop effective clinical interventions.
中风后中枢性疼痛（CPSP）是一种中风后出现的医学并发症，会显著影响患者的生活质量和社会功能。尽管研究仍在进行，但CPSP的确切发病机制尚不清楚，且目前仍缺乏切实可行的治疗方法。我们的综述旨在系统分析当前关于CPSP的临床和临床前研究，这对于找出知识空白和指导有效疗法的开发至关重要。该综述将基于临床研究阐明CPSP的临床特征、评估量表和当代治疗方法。它将特别强调由中风引发的CPSP模型，揭示其潜在机制并评估在临床前研究中得到验证的治疗方法。此外，该综述不仅会突出动物试验中的方法学局限性，还会为研究人员提供具体建议，以提高未来研究的质量并指导有效疗法的开发。预计本综述将为当前有关CPSP的知识提供有价值的见解，并可作为未来研究和临床实践的指南。该综述将有助于对CPSP进行科学理解，并有助于开发有效的临床干预措施。
