Takayama Yoshihiro, Shimakawa Yusuke, Aizawa Yoshiaki, Butcher Christian, Chibana Naomi, Collins Mary, Kamegai Kohei, Kim Tae Gyun, Koyama Satoshi, Matsuyama Ryota, Matthews Melissa M, Mori Tomoari, Nagamoto Tetsuharu, Narita Masashi, Omori Ryosuke, Shibata Noriko, Shibata Satoshi, Shiiki Souichi, Takakura Shunichi, Toyozato Naoki, Tsuchiya Hiroyuki, Wolf Matthias, Yamamoto Taro, Yokoyama Shuhei, Yonaha Sho, Mizumoto Kenji
Okinawa Prefecture Commission for Epidemiological and Statistical Analysis, Japan.
Division of Infectious Diseases, Department of Internal Medicine, Okinawa Prefectural Chubu Hospital, Japan.
Jpn J Infect Dis. 2025 Jan 23;78(1):8-18. doi: 10.7883/yoken.JJID.2023.255. Epub 2024 Sep 30.
We estimated the seroprevalence of anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) immunoglobulin G (IgG) in different island groups in Okinawa. A cross-sectional serosurvey was conducted over three periods between July 2020 and February 2021. A total of 2,683 serum samples were collected from six referral medical centers, each covering a separate region in Okinawa. In the main island, the seroprevalence was 0.0% (0/392; 95% confidence interval (CI), 0.0- 0.9%), 0.6% (8/1,448, 0.2-1.1%), and 1.4% (8/582, 0.6-2.7%) during the 1st, 2nd, and 3rd serosurvey, respectively. In remote islands, the seroprevalence was 0.0% (0/144; 95% CI, 0.0-2.5%) and 1.6% (2/123, 0.2-5.8%) during the 2nd and 3rd survey, respectively. The case detection ratio was 2.7 (95% CI, 1.3-5.3) in the main island and 2.8 (0.7-11.1) in remote islands during the 3rd survey. The case detection ratio was the highest in individuals aged 20-29 years (8.3; 95% CI, 3.3-21.4) in the main island and in those aged 50-59 years (14.1; 2.1-92.7) in remote islands, suggesting underreporting of clinical cases by the surveillance system in these subgroups. A serosurvey conducted during an emerging infectious disease epidemic can be useful for validating the reliability of the surveillance system by providing case detection ratio.
我们估算了冲绳不同岛屿群组中抗严重急性呼吸综合征冠状病毒2（抗SARS-CoV-2）免疫球蛋白G（IgG）的血清阳性率。在2020年7月至2021年2月期间的三个时间段开展了一项横断面血清学调查。总共从六个转诊医疗中心收集了2683份血清样本，每个医疗中心覆盖冲绳的一个独立区域。在主岛，第一次、第二次和第三次血清学调查期间的血清阳性率分别为0.0%（0/392；95%置信区间（CI），0.0 - 0.9%）、0.6%（8/1448，0.2 - 1.1%）和1.4%（8/582，0.6 - 2.7%）。在偏远岛屿，第二次和第三次调查期间的血清阳性率分别为0.0%（0/144；95%CI，0.0 - 2.5%）和1.6%（2/123，0.2 - 5.8%）。在第三次调查期间，主岛的病例检出率为2.7（95%CI，1.3 - 5.3），偏远岛屿为2.8（0.7 - 11.1）。在主岛，20 - 29岁人群的病例检出率最高（8.3；95%CI，3.3 - 21.4），在偏远岛屿则是50 - 59岁人群最高（14.1；2.1 - 92.7），这表明这些亚组中的临床病例存在监测系统报告不足的情况。在新发传染病流行期间进行血清学调查，通过提供病例检出率，有助于验证监测系统的可靠性。
