Xu Weipan, Zhou Xingzhi
Department of Orthopedics, Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University, Shaoxing 312099, Zhejiang Province, China.
Department of Orthopedics, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Oct 25;53(5):641-649. doi: 10.3724/zdxbyxb-2024-0024.
Microspheres are a novel drug delivery system, which provides a new approach for cancer therapy. Anti-cancer agents loaded in microspheres can be released in a controlled and sustained pattern, thereby enhancing the therapeutic efficacy and reducing the side effects and toxicity. The preparation methods for drug delivery microspheres include solvent evaporation, phase separation, spray drying, and microfluidic technology, each of these have advantages and limitations. Based on the preparation materials, drug delivery microspheres can be categorized into natural polymer microspheres, synthetic polymer microspheres and bioceramic microspheres. Natural polymer micro-spheres have good biocompatibility and degradability; synthetic polymer microspheres exhibit superior mechanical properties; bioceramic microspheres have good biocompatibility and specific biological functions, which are widely used in bone tissue engineering. Drug delivery microspheres are used for cancer treatment in various modalities, including photothermal therapy, photodynamic therapy, radioembolization, and immunotherapy, as well as chemotherapy. This article reviews the recent progress of microspheres as nano drug delivery system in cancer treatment to provide a reference for further clinical and translation research.
微球是一种新型药物递送系统，为癌症治疗提供了一种新方法。负载于微球中的抗癌药物能够以可控且持续的方式释放，从而提高治疗效果并降低副作用和毒性。药物递送微球的制备方法包括溶剂蒸发法、相分离法、喷雾干燥法和微流控技术，这些方法各有优缺点。基于制备材料，药物递送微球可分为天然聚合物微球、合成聚合物微球和生物陶瓷微球。天然聚合物微球具有良好的生物相容性和可降解性；合成聚合物微球表现出优异的机械性能；生物陶瓷微球具有良好的生物相容性和特定的生物学功能，广泛应用于骨组织工程。药物递送微球用于多种癌症治疗方式，包括光热疗法、光动力疗法、放射性栓塞疗法、免疫疗法以及化疗。本文综述了微球作为纳米药物递送系统在癌症治疗方面的最新进展，为进一步的临床和转化研究提供参考。
