Nanobiotechnology Laboratory, Biology Department, Faculty of Science, Razi University, Iran.
Department of Chemical Engineering, Northeastern University, Boston, USA.
Bioorg Med Chem. 2021 Mar 1;33:116028. doi: 10.1016/j.bmc.2021.116028. Epub 2021 Jan 19.
Polymeric microspheres (MSs) and nanospheres (NSs) composed of synthetic and natural polymers can encapsulate anticancer drugs, among other therapeutics, acting as drug carriers to release them at controlled rates over long periods of time. These carriers present several potential advantages including simple preparation methods, suitable control over the sustained release of medications or stem cells, triggered release resulting from stimulus-responsive delivery, improved physical properties such as porosity and stable scaffolds for tissue engineering, and possible applications as microreactors and nanoreactors compared to conventional drug delivery systems. Moreover, many of these factors can impact drug release rates by polymeric MSs and NSs. Herein, drug delivery systems based on polymeric MSs and NSs are described and compared according to recent advances and challenges, and poignant thoughts on what the field needs to progress are presented.
聚合物微球 (MSs) 和纳米球 (NSs) 由合成和天然聚合物组成，可封装抗癌药物和其他治疗药物，作为药物载体，以可控的速率长时间释放药物。这些载体具有几个潜在的优势，包括简单的制备方法、对药物或干细胞的持续释放的适当控制、刺激响应性输送引起的触发释放、改善物理性质（如多孔性和稳定的组织工程支架）以及作为微反应器和纳米反应器的可能应用，与传统的药物输送系统相比。此外，这些因素中的许多因素都会影响聚合物 MSs 和 NSs 的药物释放速率。本文根据最新进展和挑战，对基于聚合物 MSs 和 NSs 的药物输送系统进行了描述和比较，并提出了该领域需要取得进展的深刻思考。
