一种砷代脂肪酸（As-FA 362）和一种砷代烃（As-HC 444）的改进合成方法。
Improved Syntheses of an Arseno-Fatty Acid (As-FA 362) and an Arseno-Hydrocarbon (As-HC 444).
作者信息
Chacon-Teran Miguel A, Bhattacharjee Shubhra, Bailoo Jeremy D, Deonarine Amrika, Findlater Michael
机构信息
Department of Chemistry and Biochemistry, University of California, Merced, 5200 Lake Rd, Merced, CA 95343, USA.
Department of Civil, Environmental and Construction Engineering, Texas Tech University, Lubbock, TX 79409, USA.
出版信息
Synthesis (Stuttg). 2023 Dec;55(24):4091-4095. doi: 10.1055/a-2122-4287. Epub 2023 Aug 17.
Robust and reliable synthetic methods have been developed for the preparation of an arseno-fatty acid (As-FA362) and an arseno-hydrocarbon (As-HC444). An improved route to access the starting materials necessary for the new synthetic routes is also disclosed. With these improvements, an increased accessibility to arsenic-containing compounds is anticipated, which may be deployed as standards required for the development of quantitative methods in biological matrices. For the first time, stability data for these compounds are reported. With these results in hand, data on the elimination profile, bioaccumulation potential and patho-behavioral and physiological consequences of these organoarsenicals are planned.
已经开发出了用于制备砷代脂肪酸（As-FA362）和砷代烃（As-HC444）的稳健且可靠的合成方法。还公开了一种改进的途径来获取新合成路线所需的起始原料。有了这些改进，预计含砷化合物的可及性会提高，这些化合物可作为生物基质中定量方法开发所需的标准物质。首次报道了这些化合物的稳定性数据。基于这些结果，计划获取有关这些有机砷化合物的消除概况、生物累积潜力以及病理行为和生理后果的数据。
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