Sun Hongmei, Cao Yuyu, Zhai Beibei, Zhao Xiaoshuang, Zhang Xuejun, Su Jiangtao
National '111' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Key Laboratory of Industrial Microbiology in Hubei, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), School of Life Science and Health, Hubei University of Technology, Wuhan 430068, China.
Hubei Bio-Pharmaceutical Industrial-Technological Institute Inc., Wuhan, Hubei 430075, China.
Int J Pharm X. 2024 Sep 17;8:100286. doi: 10.1016/j.ijpx.2024.100286. eCollection 2024 Dec.
Nanotechnology has attracted extensive attention in the diagnosis and treatment of cancer. Therefore, the research aimed at developing new nanomaterials and exploring their applications in biomedicine has attracted more attention. In this study, BiS-Au nanoclusters (BiS-AuNCs) as fluorescence/infrared thermal imaging-guided photothermal therapy (PTT) was prepared for the first time. It was achieved in a facile and mild way by optimizing the amount of Bi and Au using bovine serum albumin (BSA) as reducer and stabilizer. The as-prepared BiS-AuNCs with special morphology showed high stability, excellent biocompatibility and good photostability. Apart from these, it also can accumulate at tumor sites and exhibit considerable fluorescence/infrared thermal imaging-guided PTT. BiS-AuNCs nanoparticles integrate imaging and therapeutic functions into an advanced application platform, which provides the possibility to build a novel nano-cancer diagnosis and treatment platform.
纳米技术在癌症诊断和治疗方面已引起广泛关注。因此，旨在开发新型纳米材料并探索其在生物医学中的应用的研究受到了更多关注。在本研究中，首次制备了用于荧光/红外热成像引导光热治疗（PTT）的铋-金纳米团簇（BiS-AuNCs）。通过使用牛血清白蛋白（BSA）作为还原剂和稳定剂来优化铋和金的用量，以简便温和的方式实现了这一目标。所制备的具有特殊形态的BiS-AuNCs表现出高稳定性、优异的生物相容性和良好的光稳定性。除此之外，它还能在肿瘤部位积聚，并展现出可观的荧光/红外热成像引导的光热治疗效果。BiS-AuNCs纳米颗粒将成像和治疗功能集成到一个先进的应用平台中，这为构建新型纳米癌症诊断和治疗平台提供了可能性。
