Li Xuefeng, Zhu Yang, Yu Tao, Cao Liyu, Sun Aimin, Hu Zongtao
Department of Thoracic Oncology, Hefei Cancer Hospital, Chinese Academy of Sciences, No. 68 Yangqiao Road, Hefei, 230000, China.
Department of Respiratory, Fuyang Hospital of Anhui Medical University, No. 99 Huangshan Road, Fuyang, 236000, China.
Respir Med Case Rep. 2024 Sep 17;52:102114. doi: 10.1016/j.rmcr.2024.102114. eCollection 2024.
Extranodal Natural Killer/T Cell Lymphoma Nasal Type (EN-NK/T-CL-NT) is a rare type of non-Hodgkin lymphoma in which the lesion is usually located in the upper respiratory tract, such as nasal cavity, palate, and nasopharynx. In addition, the primary lesion of EN-NK/T-CL-NT can rarely originate in extranasal sites such as the skin, gastrointestinal tract, testicles, central nervous system, and lungs. We describe an 82-year-old male smoker was brought to the hospital with 8 months of fever, cough, sputum production, chest pain, and chest tightness. Computed tomography (CT) of the chest showed subpleural high-density shadow in the lower lobe of the right lung with unclear borders and surrounding patchy ground-glass shadow. Initially, the patient's right lower lobe lesion progressed after receiving anti-inflammatory treatment. He subsequently underwent two computerized tomography (CT)-guided percutaneous transthoracic needle aspiration biopsies and a bronchoscopy, but no tumor cells were found. Through multidisciplinary team discussions, the patient was then transferred to the department of cardiothoracic surgery for right lower lobectomy. Finally, extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type, was confirmed by pathology of the surgical specimen. The diagnosis of primary pulmonary ENKTCL was made because no evidence other than extrapulmonary site was found at the time of diagnosis and treatment. Here we report a case of primary pulmonary extranodal natural killer/T-cell lymphoma of nasal type presenting as pneumonia in the right lower lobe and enhance the understanding of the disease.
结外鼻型自然杀伤/T细胞淋巴瘤（EN-NK/T-CL-NT）是一种罕见的非霍奇金淋巴瘤，其病变通常位于上呼吸道，如鼻腔、腭部和鼻咽部。此外，EN-NK/T-CL-NT的原发病变很少起源于鼻外部位，如皮肤、胃肠道、睾丸、中枢神经系统和肺部。我们描述了一名82岁的男性吸烟者，因发热、咳嗽、咳痰、胸痛和胸闷8个月而入院。胸部计算机断层扫描（CT）显示右肺下叶胸膜下高密度影，边界不清，周围有斑片状磨玻璃影。最初，患者在接受抗炎治疗后右肺下叶病变进展。随后，他接受了两次计算机断层扫描（CT）引导下经皮经胸针吸活检和一次支气管镜检查，但未发现肿瘤细胞。通过多学科团队讨论，患者随后被转至心胸外科行右下肺叶切除术。最后，手术标本病理证实为结外鼻型自然杀伤/T细胞淋巴瘤（ENKTCL）。由于在诊断和治疗时未发现肺外部位以外的证据，故诊断为原发性肺ENKTCL。在此，我们报告一例以右下叶肺炎表现的原发性肺结外鼻型自然杀伤/T细胞淋巴瘤病例，以增进对该疾病的认识。
