Prognostic impact of mutations on acute myeloid leukemia.

BACKGROUND

Interleukin-7 receptor () mutation has been demonstrated to be an adverse prognostic factor in acute lymphoblastic leukemia (ALL) patients. However, the effects of the mutation on acute myeloid leukemia (AML) have rarely been reported. Here, we investigated mutations and their effects on AML patients.

METHODS

A total of 346 newly diagnosed AML patients from January 2017 to July 2020 at Nanfang Hospital were analyzed in this study. A genomic panel of 167 gene targets was detected by next-generation sequencing.

RESULTS

Among 346 patients, 33 (9.5%) AML patients carried mutations. With a median follow-up of 50.7 months (95% confidence interval (CI) 17.3-62.2), the 5-year overall survival (OS) rates were 51.5% (95% CI 37.0%-71.0%) and 72.2% (95% CI 67.4%-77.3%;  = 0.008), the 5-year event-free survival (EFS) rates were 36.1% (95% CI 23.2%-57.1%) and 58.1% (95% CI 52.9%-63.8%;  = 0.005), the 5-year non-relapse mortality (NRM) were 21.4% (95% CI 8.5%-38.2%) and 6.2% (95% CI 3.7%-9.5%;  = 0.004) in the IL7R mutant ( ) group and non-IL7R mutant ( ) group, respectively. There is no significant difference in the disease-free survival (75.1% vs 73.5%,  = 0.885) and cumulative incidence of relapse (25.7% vs 25.2%,  = 0.933) between and group. Furthermore, patients who underwent hematopoietic stem cell transplantation (HSCT) still had more adverse outcomes in the group than in the group (5-year OS: 61.9% vs 85.3%,  = 0.003). In the ( = 0.013) and DNA methyltransferase 3A ( = 0.046) mutation subgroups, the presence of mutations was associated with worse OS than in AML patients without mutations.

CONCLUSION

Our study demonstrated that the mutation is associated with an inferior prognosis for AML patients. Patients with mutations have higher NRM, shorter OS, and EFS than patients without mutations, even patients who have undergone HSCT. Future larger and multicentric prospective studies will be explored.