Bohman Matthew H, Kall Hunter, Miner Andrew
Dermatology, Burrell College of Osteopathic Medicine, Las Cruces, USA.
Dermatology, Brevard Skin and Cancer Center, Rockledge, USA.
Cureus. 2024 Aug 29;16(8):e68128. doi: 10.7759/cureus.68128. eCollection 2024 Aug.
Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare, challenging condition characterized by its acute febrile onset, neutrophilic dermal infiltrate seen on histology, and frequent association with hematologic disorders. This case report presents a longitudinal follow-up of NDDH in an 80-year-old male with significant comorbid conditions, including atrial fibrillation, chronic systolic heart failure, venous insufficiency, and gastroesophageal reflux disease. Over six clinic visits, we document the patient's clinical progression, highlighting key changes in presentation, diagnostic findings, and the multifaceted approach to management, including the use of systemic and topical therapies. Notably, the treatment strategy was adapted in response to diagnostic tests revealing methicillin-resistant (MRSA) and Group B (GBS), complicating the patient's condition. Despite the challenges posed by the patient's comorbidities, which limited the use of certain medications, the patient showed significant improvement with a treatment approach primarily involving topical and systemic steroids. The observed improvement emphasizes the effectiveness of modifying therapy based on lesion regression and the patient's overall condition. This case underscores the critical need for accurate diagnosis, the complexities of managing NDDH in patients with multiple health conditions, and the value of adaptability in treatment plans. Through this detailed longitudinal case study, we contribute insights into the progression and management of NDDH, emphasizing the need for ongoing research and a flexible approach to treatment.
手背嗜中性皮病(NDDH)是一种罕见且具有挑战性的病症,其特征为急性发热起病、组织学上可见嗜中性真皮浸润,且常与血液系统疾病相关。本病例报告展示了一名80岁男性NDDH患者的纵向随访情况,该患者患有多种严重合并症,包括心房颤动、慢性收缩性心力衰竭、静脉功能不全和胃食管反流病。在六次门诊就诊过程中,我们记录了患者的临床进展,重点突出了临床表现、诊断结果的关键变化以及多方面的管理方法,包括全身和局部治疗的使用。值得注意的是,治疗策略根据诊断测试发现耐甲氧西林金黄色葡萄球菌(MRSA)和B组链球菌(GBS)而进行了调整,这使患者病情复杂化。尽管患者的合并症带来了挑战,限制了某些药物的使用,但主要采用局部和全身类固醇的治疗方法使患者有了显著改善。观察到的改善强调了根据皮损消退和患者整体状况调整治疗的有效性。本病例强调了准确诊断的迫切需求、在患有多种健康问题的患者中管理NDDH的复杂性以及治疗计划中灵活性的价值。通过这个详细的纵向病例研究,我们为NDDH的进展和管理提供了见解,强调了持续研究和灵活治疗方法的必要性。