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手背嗜中性皮病的纵向表现及管理:一例六次就诊的病例报告

Longitudinal Presentation and Management of Neutrophilic Dermatosis of the Dorsal Hand: A Case Report Over Six Visits.

作者信息

Bohman Matthew H, Kall Hunter, Miner Andrew

机构信息

Dermatology, Burrell College of Osteopathic Medicine, Las Cruces, USA.

Dermatology, Brevard Skin and Cancer Center, Rockledge, USA.

出版信息

Cureus. 2024 Aug 29;16(8):e68128. doi: 10.7759/cureus.68128. eCollection 2024 Aug.

DOI:10.7759/cureus.68128
PMID:39347155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438556/
Abstract

Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare, challenging condition characterized by its acute febrile onset, neutrophilic dermal infiltrate seen on histology, and frequent association with hematologic disorders. This case report presents a longitudinal follow-up of NDDH in an 80-year-old male with significant comorbid conditions, including atrial fibrillation, chronic systolic heart failure, venous insufficiency, and gastroesophageal reflux disease. Over six clinic visits, we document the patient's clinical progression, highlighting key changes in presentation, diagnostic findings, and the multifaceted approach to management, including the use of systemic and topical therapies. Notably, the treatment strategy was adapted in response to diagnostic tests revealing methicillin-resistant (MRSA) and Group B (GBS), complicating the patient's condition. Despite the challenges posed by the patient's comorbidities, which limited the use of certain medications, the patient showed significant improvement with a treatment approach primarily involving topical and systemic steroids. The observed improvement emphasizes the effectiveness of modifying therapy based on lesion regression and the patient's overall condition. This case underscores the critical need for accurate diagnosis, the complexities of managing NDDH in patients with multiple health conditions, and the value of adaptability in treatment plans. Through this detailed longitudinal case study, we contribute insights into the progression and management of NDDH, emphasizing the need for ongoing research and a flexible approach to treatment.

摘要

手背嗜中性皮病(NDDH)是一种罕见且具有挑战性的病症,其特征为急性发热起病、组织学上可见嗜中性真皮浸润,且常与血液系统疾病相关。本病例报告展示了一名80岁男性NDDH患者的纵向随访情况,该患者患有多种严重合并症,包括心房颤动、慢性收缩性心力衰竭、静脉功能不全和胃食管反流病。在六次门诊就诊过程中,我们记录了患者的临床进展,重点突出了临床表现、诊断结果的关键变化以及多方面的管理方法,包括全身和局部治疗的使用。值得注意的是,治疗策略根据诊断测试发现耐甲氧西林金黄色葡萄球菌(MRSA)和B组链球菌(GBS)而进行了调整,这使患者病情复杂化。尽管患者的合并症带来了挑战,限制了某些药物的使用,但主要采用局部和全身类固醇的治疗方法使患者有了显著改善。观察到的改善强调了根据皮损消退和患者整体状况调整治疗的有效性。本病例强调了准确诊断的迫切需求、在患有多种健康问题的患者中管理NDDH的复杂性以及治疗计划中灵活性的价值。通过这个详细的纵向病例研究,我们为NDDH的进展和管理提供了见解,强调了持续研究和灵活治疗方法的必要性。

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Cureus. 2024 Aug 29;16(8):e68128. doi: 10.7759/cureus.68128. eCollection 2024 Aug.
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本文引用的文献

1
Sweet Syndrome and Neutrophilic Dermatosis of the Dorsal Hands.Sweet 综合征和手背中性粒细胞皮肤病。
Dermatol Clin. 2024 Apr;42(2):193-207. doi: 10.1016/j.det.2023.08.007. Epub 2023 Sep 9.
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Neutrophilic dermatosis of the dorsal hands: A review of 123 cases.手背中性粒细胞皮肤病:123 例病例回顾。
J Am Acad Dermatol. 2023 Jun;88(6):1338-1344. doi: 10.1016/j.jaad.2019.08.070. Epub 2019 Sep 6.
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Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases.中性粒细胞介导的皮肤疾病中的炎症机制。
Front Immunol. 2019 May 8;10:1059. doi: 10.3389/fimmu.2019.01059. eCollection 2019.
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Clinical Features of Neutrophilic Dermatosis Variants Resembling Necrotizing Fasciitis.中性粒细胞皮肤病类似坏死性筋膜炎的临床特征。
JAMA Dermatol. 2019 Jan 1;155(1):79-84. doi: 10.1001/jamadermatol.2018.3890.
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Neutrophilic Dermatosis of the Hands: A Review of 17 Cases.手部嗜中性皮病:17例病例回顾
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Insight into Sweet's syndrome and associated-malignancy: a review of the current literature.深入了解Sweet 综合征及伴发恶性肿瘤:对当前文献的综述。
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Neutrophilic dermatoses: a review of current treatment options.嗜中性皮肤病:当前治疗选择综述
Am J Clin Dermatol. 2009;10(5):301-12. doi: 10.2165/11310730-000000000-00000.
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Neutrophilic dermatosis of the hands: an underrecognized hematological condition that may result in unnecessary surgery.手部嗜中性皮病:一种未被充分认识的血液系统疾病,可能导致不必要的手术。
Am J Hematol. 2009 Jan;84(1):60-1. doi: 10.1002/ajh.21173.
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Sweet's syndrome--a comprehensive review of an acute febrile neutrophilic dermatosis.斯威特综合征——急性发热性嗜中性皮病的全面综述
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The relationship between neutrophilic dermatosis of the dorsal hands and sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum.手背嗜中性皮病与Sweet综合征的关系:9例报告及与非典型坏疽性脓皮病的比较
Arch Dermatol. 2006 Jan;142(1):57-63. doi: 10.1001/archderm.142.1.57.