Zuhairi Alyaa K, Almomin Ammar M, Alhubaish Emad, Mansour Abbas A
Endocrinology and Diabetes, Faiha Specialized Diabetes, Endocrine and Metabolism Center, University of Basrah, Basrah, IRQ.
Cureus. 2024 Aug 28;16(8):e67990. doi: 10.7759/cureus.67990. eCollection 2024 Aug.
Background Determining the causes of female hypogonadism is crucial for guiding management and preventing complications. This study aimed to categorize the causes of female hypogonadism in Basrah and identify its frequency. Methodology This retrospective single-center study analyzed 1,111 women diagnosed with hypogonadism between 2008 and 2024 and described its etiology in women less than 45 years old (before menopause). The study was conducted in the Faiha Specialized Diabetes, Endocrine and Metabolism Center in Basrah, southern Iraq. Cases were classified into hypogonadotropic hypogonadism and hypergonadotropic hypogonadism according to specific causes such as disorders of sex development or difference (DSDs). Results The most frequent etiology in the 1,111 patients was hypogonadotropic hypogonadism, documented in 844 (76%) cases; functional amenorrhea was predominant in 402 (47.63%) of them. Next were 218 (20%) cases of hypergonadotropic hypogonadism. DSDs were documented in a small percentage of female hypogonadism cases; in only 49 (4%) cases was congenital adrenal hyperplasia the most common (57.14%). Conclusions The results of this study provide useful clinical insights into the frequency of female hypogonadism in Basrah.
确定女性性腺功能减退的病因对于指导治疗和预防并发症至关重要。本研究旨在对巴士拉女性性腺功能减退的病因进行分类并确定其发生率。方法：这项回顾性单中心研究分析了2008年至2024年间诊断为性腺功能减退的1111名女性，并描述了45岁以下（绝经前）女性的病因。该研究在伊拉克南部巴士拉的法伊哈糖尿病、内分泌和代谢专科医院进行。根据性发育障碍或差异（DSD）等特定病因，将病例分为低促性腺激素性性腺功能减退和高促性腺激素性性腺功能减退。结果：1111例患者中最常见的病因是低促性腺激素性性腺功能减退，有844例（76%）；其中功能性闭经占402例（47.63%）。其次是218例（20%）高促性腺激素性性腺功能减退。DSD在一小部分女性性腺功能减退病例中被记录；只有49例（4%）先天性肾上腺皮质增生最为常见（57.14%）。结论：本研究结果为巴士拉女性性腺功能减退的发生率提供了有用的临床见解。
