Tam Ryan, Howard Stephen, Jimenez-Artiles Massiel, Sharma Meenal, Makdisy Fady
Internal Medicine, Lake Erie College of Osteopathic Medicine, Rochester, USA.
Physical Medicine and Rehabilitation, Lake Erie College of Osteopathic Medicine, Rochester, USA.
Cureus. 2024 Aug 30;16(8):e68229. doi: 10.7759/cureus.68229. eCollection 2024 Aug.
Neurosarcoidosis is a disease in which noncaseating granulomas, characteristic of sarcoidosis, are found within organs of the nervous system such as the brain and spinal cord. This case report highlights a 57-year-old male with worsening bilateral lower extremity weakness and numbness in addition to ptosis and oculomotor nerve palsy of the right eye. Computed tomography (CT) imaging showed mediastinal and hilar lymphadenopathy, which raised suspicion for neurosarcoidosis. Multiple biopsies were taken from lymph nodes in the mediastinal region, which resulted in non-necrotizing epithelioid cell granulomas, consistent with the suspected neurosarcoidosis. Medical providers must include neurosarcoidosis within a much broader differential diagnosis when encountering patients that present with a similar presentation shown in this case report so that treatment can be promptly initiated as soon as possible.
神经结节病是一种在神经系统器官(如脑和脊髓)中发现非干酪样肉芽肿(结节病的特征性表现)的疾病。本病例报告重点介绍了一名57岁男性,除了右眼上睑下垂和动眼神经麻痹外,还出现双侧下肢无力和麻木症状加重。计算机断层扫描(CT)成像显示纵隔和肺门淋巴结肿大,这增加了神经结节病的怀疑。从纵隔区域的淋巴结进行了多次活检,结果显示为非坏死性上皮样细胞肉芽肿,与疑似神经结节病一致。当遇到表现与本病例报告相似的患者时,医疗人员必须在更广泛的鉴别诊断中考虑神经结节病,以便尽快及时开始治疗。