急性中心性浆液性脉络膜视网膜病变患者单核细胞/高密度脂蛋白比值和中性粒细胞/淋巴细胞比值。
Monocyte to high-density lipoprotein and neutrophil-to-lymphocyte ratios in patients with acute central serous chorioretinopathy.
机构信息
Department of Ophthalmology, The Kayseri City Hospital, Kayseri, Turkey.
出版信息
Indian J Ophthalmol. 2020 May;68(5):854-858. doi: 10.4103/ijo.IJO_1327_19.
PURPOSE
To investigate monocyte to high-density lipoprotein (HDL) ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) as indicators of systemic inflammation in acute central serous chorioretinopathy (CSC).
METHODS
The HDL levels, hematological profiles, erythrocyte sedimentation rates (ESR), and C-reactive protein (CRP) levels of 38 patients with acute CSC (Group I) and 38 controls without CSC (Group II) were measured.
RESULTS
MHRs were significantly higher in Group I (13.30 ± 2.95) than in Group II (11.52 ± 2.42, P = 0.005), whereas NLRs, CRP values, and ESR values did not significantly differ between the groups (P = 0.726, P = 0.219, and P = 0.441, respectively). Multivariate analysis revealed that the MHR was an independent predictor of acute CSC (OR = 1.266, 95% CI = 1.054-1.521, P = 0.012).
CONCLUSION
Indicating an association between increased MHRs and acute CSC, the MHR might represent simple, inexpensive, reliable biomarkers of inflammation in acute CSC.
目的
探讨单核细胞与高密度脂蛋白（HDL）比值（MHR）和中性粒细胞与淋巴细胞比值（NLR）作为急性中心性浆液性脉络膜视网膜病变（CSC）全身炎症的指标。
方法
测量 38 例急性 CSC 患者（I 组）和 38 例无 CSC 对照组（II 组）的 HDL 水平、血液学特征、红细胞沉降率（ESR）和 C 反应蛋白（CRP）水平。
结果
I 组的 MHRs（13.30 ± 2.95）明显高于 II 组（11.52 ± 2.42，P = 0.005），而 NLRs、CRP 值和 ESR 值在两组之间无显著差异（P = 0.726、P = 0.219 和 P = 0.441）。多变量分析显示，MHR 是急性 CSC 的独立预测因子（OR = 1.266，95%CI = 1.054-1.521，P = 0.012）。
结论
MHR 与急性 CSC 之间存在相关性，表明 MHR 可能是急性 CSC 炎症的简单、廉价、可靠的生物标志物。
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