Moffa Simona, Sorice Gian Pio, Di Giuseppe Gianfranco, Cinti Francesca, Ciccarelli Gea, Soldovieri Laura, Brunetti Michela, Sonnino Rebecca, Nista Enrico C, Gasbarrini Antonio, Pontecorvi Alfredo, Mezza Teresa, Giaccari Andrea
Centro per le Malattie Endocrine e Metaboliche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Sezione di Medicina Interna, Endocrinologia, Andrologia e Malattie Metaboliche, Dipartimento di Medicina di Precisione e Rigenerativa e Area Jonica - (DiMePre-J), Università Degli Studi di Bari "Aldo Moro", Bari, Italy.
J Endocrinol Invest. 2025 Feb;48(2):455-464. doi: 10.1007/s40618-024-02438-8. Epub 2024 Sep 30.
Physical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a healthy glucose metabolism even in healthy subjects. To date, no studies have investigated the effect of a single bout of aerobic physical exercise on glucose metabolism in young, moderately active, healthy adults.
We performed an OGTT 7 days before and 24 h after a single bout of physical exercise, to evaluate 1-hour post-load plasma glucose and surrogate indexes of insulin sensitivity and insulin secretion.
Glucose levels were significantly reduced after exercise at baseline and one hour after glucose load; similarly, insulin was significantly lower 1 h after glucose load. We found a significant increase in the Matsuda index, confirmed by OGIS index, QUICKI index, and by significant reduction in HOMA-IR. Conversely, we observed a trend to increase in HOMA-B.
This is the first study to evaluate the effect of a single bout of exercise on 1-hour glucose levels following OGTT. We found a significant reduction in 1-hour glucose levels following OGTT together with an increased insulin sensitivity. A single 30-minute bout of aerobic exercise also seemed to improve the insulin secretion pattern. Modifications in beta cell secretory capacity during exercise are likely secondary to an improvement in insulin action in insulin dependent tissues.
体育锻炼是2型糖尿病治疗的关键组成部分，即使在健康受试者中，对维持健康的葡萄糖代谢也起着重要作用。迄今为止，尚无研究调查单次有氧运动对年轻、中度活跃的健康成年人葡萄糖代谢的影响。
我们在单次体育锻炼前7天和锻炼后24小时进行了口服葡萄糖耐量试验（OGTT），以评估负荷后1小时的血浆葡萄糖以及胰岛素敏感性和胰岛素分泌的替代指标。
运动后基线及葡萄糖负荷后1小时的血糖水平显著降低；同样，葡萄糖负荷后1小时胰岛素水平显著降低。我们发现松田指数显著增加，OGIS指数、QUICKI指数也证实了这一点，同时HOMA-IR显著降低。相反，我们观察到HOMA-B有增加的趋势。
这是第一项评估单次运动对OGTT后1小时血糖水平影响的研究。我们发现OGTT后1小时血糖水平显著降低，同时胰岛素敏感性增加。单次30分钟的有氧运动似乎也改善了胰岛素分泌模式。运动期间β细胞分泌能力的改变可能继发于胰岛素依赖组织中胰岛素作用的改善。
