在F-FDG PET-CT上被误诊为肾上腺皮质癌的良性纯分泌雄激素肾上腺肿瘤：一例罕见病例报告
Benign pure androgen-secreting adrenal tumor misdiagnosed as adrenocortical carcinoma on F-FDG PET-CT: a rare case report.
作者信息
Wang Zhan, Chen Jiayang, Shi Xiaohua, Liu Yi, Wang Wenda, Zheng Guoyang, Zhao Yang, Li Yanan, Wang Xu, Qiu Dongxu, Zhang Yushi
机构信息
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 100730, Beijing, China.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 100730, Beijing, China.
出版信息
Endocrine. 2025 Feb;87(2):481-485. doi: 10.1007/s12020-024-04059-w. Epub 2024 Sep 30.
BACKGROUND
Adult pure androgen-secreting adrenal tumors (PASATs) are rarely reported and the malignancy of such tumor are difficult to confirm before surgery. Here we report a PASAT demonstrating extremely F-FDG uptake turned out to benign tumor by postoperative pathology examination.
CASE PRESENTATION
A 19-year-old adolescent found a tumor measuring 7.2 cm located in the right adrenal region on enhanced CT during the routine physical examination. Signs of virilization and elevated testosterone and dehydroepiandrosterone (DHEA) were verified during preoperative examination. F-FDG PET/CT revealed the tumor had an extremely high F-FDG uptake with a SUVmax reaching 42.7, which turned out to be oncocytic adrenocortical adenoma by pathological examination.
CONCLUSIONS
F-FDG PET/CT may be limited in assessing the malignancy of PASAT.
背景
成人纯雄激素分泌性肾上腺肿瘤（PASAT）鲜有报道，且此类肿瘤的恶性程度在术前难以确诊。在此我们报告一例PASAT，其表现为极高的氟代脱氧葡萄糖（F-FDG）摄取，术后病理检查结果显示为良性肿瘤。
病例介绍
一名19岁青少年在常规体检的增强CT检查中发现右肾上腺区有一个7.2厘米的肿瘤。术前检查证实有男性化体征以及睾酮和脱氢表雄酮（DHEA）升高。F-FDG PET/CT显示该肿瘤具有极高的F-FDG摄取，最大标准化摄取值（SUVmax）达到42.7，病理检查结果为嗜酸细胞性肾上腺皮质腺瘤。
结论
F-FDG PET/CT在评估PASAT的恶性程度方面可能存在局限性。
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