头颈部癌中氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）与Ki-67指数的相关性：一项荟萃分析。
Associations between FDG-PET and Ki 67-index in head and neck cancer: A meta-analysis.
作者信息
Meyer Hans-Jonas, Gundermann Peter, Surov Alexey
机构信息
Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig.
Department of Diagnostic and Interventional Radiology, University of Ulm, Ulm, Germany, Germany.
出版信息
Medicine (Baltimore). 2019 Oct;98(40):e17472. doi: 10.1097/MD.0000000000017472.
BACKGROUND
FDG-PET might be able to reflect histopathology features of tumors. Ki 67 in head and neck carcinomas (HNSCC). The present study sought to elucidate the association between Ki 67 index and SUVmax based upon a large patient sample.
METHODS
PubMed database was screened for studies analyzed the relationship between Ki 67 and SUV in HNSCC. Nine studies comprising 211 patients were suitable for analysis.
RESULTS
SUVmax increased with tumor grade and was statistically significant different between G1, G2, and G3 tumors. The ROC analysis for discrimination between G1/G2 and G3 tumors revealed an area under curve of 0.71. In the overall patient sample, SUVmax correlated statistically significant with Ki 67 index (r = 0.154, P = .032).
CONCLUSION
The present study identified a weak correlation between SUV values and proliferation index Ki 67 index in HNSCC in a large patient sample. Therefore, SUVmax cannot be used as surrogate parameter for proliferation activity in HNSCC.
背景
氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）或许能够反映肿瘤的组织病理学特征。头颈部癌（HNSCC）中的Ki 67。本研究旨在基于大量患者样本阐明Ki 67指数与最大标准摄取值（SUVmax）之间的关联。
方法
在PubMed数据库中筛选分析HNSCC中Ki 67与SUV关系的研究。9项包含211例患者的研究适合进行分析。
结果
SUVmax随肿瘤分级增加，在G1、G2和G3肿瘤之间差异具有统计学意义。区分G1/G2和G3肿瘤的ROC分析显示曲线下面积为0.71。在总体患者样本中，SUVmax与Ki 67指数具有统计学意义的相关性（r = 0.154，P = 0.032）。
结论
本研究在大量患者样本中发现HNSCC的SUV值与增殖指数Ki 67指数之间存在弱相关性。因此，SUVmax不能用作HNSCC增殖活性的替代参数。
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