Li Xinyang, Zhu Gaoxiang, Zhao Bing
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China.
Z Lab, bioGenous BIOTECH, Shanghai, 200438, China.
Cell Regen. 2024 Sep 30;13(1):18. doi: 10.1186/s13619-024-00203-z.
Tissue stem cells (TSCs), which reside in specialized tissues, constitute the major cell sources for tissue homeostasis and regeneration, and the contribution of transcriptional or epigenetic regulation of distinct biological processes in TSCs has been discussed in the past few decades. Meanwhile, ATP-dependent chromatin remodelers use the energy from ATP hydrolysis to remodel nucleosomes, thereby affecting chromatin dynamics and the regulation of gene expression programs in each cell type. However, the role of chromatin remodelers in tissue stem cell fate determination is less well understood. In this review, we systematically discuss recent advances in epigenetic control by chromatin remodelers of hematopoietic stem cells, intestinal epithelial stem cells, neural stem cells, and skin stem cells in their fate determination and highlight the importance of their essential role in tissue homeostasis, development, and regeneration. Moreover, the exploration of the molecular and cellular mechanisms of TSCs is crucial for advancing our understanding of tissue maintenance and for the discovery of novel therapeutic targets.
组织干细胞（TSCs）存在于特定组织中，是组织稳态和再生的主要细胞来源，在过去几十年里，人们一直在讨论TSCs中不同生物学过程的转录或表观遗传调控作用。与此同时，ATP依赖的染色质重塑因子利用ATP水解产生的能量重塑核小体，从而影响染色质动力学以及每种细胞类型中基因表达程序的调控。然而，染色质重塑因子在组织干细胞命运决定中的作用尚不太清楚。在这篇综述中，我们系统地讨论了染色质重塑因子对造血干细胞、肠上皮干细胞、神经干细胞和皮肤干细胞在其命运决定过程中的表观遗传控制的最新进展，并强调了它们在组织稳态、发育和再生中的重要作用。此外，探索TSCs的分子和细胞机制对于增进我们对组织维持的理解以及发现新的治疗靶点至关重要。
