三磷酸腺苷（ATP）依赖性染色质重塑复合体在间充质干细胞谱系特化中的作用
ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells.
作者信息
Du Wen, Guo Daimo, Du Wei
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Stem Cells Int. 2020 Sep 9;2020:8839703. doi: 10.1155/2020/8839703. eCollection 2020.
Mesenchymal stem cells (MSCs) present in multiple tissues can self-renew and differentiate into multiple lineages including the bone, cartilage, muscle, cardiac tissue, and connective tissue. Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precise gene expression regulation. ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. ATP-dependent chromatin remodeling complexes consist of a variety of subunits that together perform multiple functions in self-renewal and lineage specification. This review highlights the important role of ATP-dependent chromatin remodeling complexes and their different subunits in modulating MSC fate determination and discusses the proposed mechanisms by which ATP-dependent chromatin remodelers function.
存在于多种组织中的间充质干细胞（MSC）能够自我更新并分化为多种细胞谱系，包括骨、软骨、肌肉、心脏组织和结缔组织。细胞增殖、谱系定向和MSC分化等关键事件由精确的基因表达调控来确保。ATP依赖的染色质改变是表观遗传修饰的一种形式，它可以利用ATP水解产生的能量重组染色质结构，从而调节特定基因的转录水平。ATP依赖的染色质重塑复合物由多种亚基组成，这些亚基共同在自我更新和谱系特化中发挥多种功能。本综述强调了ATP依赖的染色质重塑复合物及其不同亚基在调节MSC命运决定中的重要作用，并讨论了ATP依赖的染色质重塑因子发挥作用的潜在机制。
Zotero 插件