Department of Neurology, Yale University, 15 York Street, New Haven, CT 06510, USA.
Department of Neurology, Yale University, 15 York Street, New Haven, CT 06510, USA; Center for Brain and Mind Health, Yale University, 15 York Street, New Haven, CT 06510, USA.
Clin Geriatr Med. 2024 Nov;40(4):597-613. doi: 10.1016/j.cger.2024.04.003. Epub 2024 May 9.
This review explores the extensive evidence linking hypertension with vascular cognitive impairment and dementia, emphasizing its role as a treatable risk factor. Drawing on observational data, it will elucidate how the chronicity of hypertension at different life stages amplifies cognitive decline risk. It explores the mechanisms underlying hypertension's association with dementia, assesses the neuroprotective properties of antihypertensive therapy, and evaluates novel blood pressure metrics and monitoring methods for their diagnostic and therapeutic potential in dementia management.
这篇综述探讨了大量证据表明高血压与血管性认知障碍和痴呆之间存在关联，强调了高血压作为可治疗的风险因素的作用。本文通过观察性数据阐明了高血压在不同生命阶段的慢性程度如何增加认知能力下降的风险。它探讨了高血压与痴呆之间关联的机制，评估了降压治疗的神经保护特性，并评估了新的血压指标和监测方法在痴呆管理中的诊断和治疗潜力。
