Xie Linxi, Zhang Hejiao, Xu Long
School of Basic Medical Science, Anhui Medical University, Hefei, Anhui, China.
Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Cell Mol Gastroenterol Hepatol. 2025;19(2):101413. doi: 10.1016/j.jcmgh.2024.101413. Epub 2024 Sep 28.
Previously, eosinophils were primarily regarded as effector toxic cells involved in allergic diseases and parasitic infections. Nevertheless, new research has shown that eosinophils are diverse and essential for immune regulation and tissue homeostasis. Their functional plasticity has been observed in patients with inflammatory diseases, cancer, infections, and other disorders. Although eosinophils are infrequently observed within the liver during periods of homeostasis, they are recruited to the liver in various liver diseases, including liver parasitosis, acute liver injury, autoimmune liver disease, and hepatocellular carcinoma. Furthermore, eosinophils have demonstrated the capacity to promote liver regeneration. This article explores the multifaceted roles of eosinophils in liver diseases, aiming to provide insights that could lead to more effective clinical therapies for these conditions.
以前，嗜酸性粒细胞主要被视为参与过敏性疾病和寄生虫感染的效应毒性细胞。然而，新的研究表明，嗜酸性粒细胞具有多样性，对免疫调节和组织稳态至关重要。在炎症性疾病、癌症、感染及其他病症患者中已观察到它们的功能可塑性。尽管在稳态期间肝脏内很少观察到嗜酸性粒细胞，但在各种肝脏疾病中，包括肝寄生虫病、急性肝损伤、自身免疫性肝病和肝细胞癌，它们会被募集到肝脏。此外，嗜酸性粒细胞已显示出促进肝脏再生的能力。本文探讨嗜酸性粒细胞在肝脏疾病中的多方面作用，旨在提供有助于为这些病症带来更有效临床治疗的见解。
