Garrido Isabel, Lopes Susana, Fonseca Elsa, Carneiro Fátima, Macedo Guilherme
Department of Gastroenterology and Hepatology, Centro Hospitalar Universitário de São João; World Gastroenterology Organization Porto Training Center; Faculty of Medicine of the University of Porto, Porto, Portugal.
Department of Pathology, Centro Hospitalar Universitário de São João; Instituto de Investigação e Inovação em Saúde (i3S) and Institute of Molecular Pathology and Immunology, University of Porto (Ipatimup); Faculty of Medicine of the University of Porto, Porto, Portugal.
World J Hepatol. 2023 Feb 27;15(2):311-317. doi: 10.4254/wjh.v15.i2.311.
Autoimmune hepatitis consists of a chronic liver disease whose etiology is unknown. It is comprised of relevant immunological aspects and of immune-mediated liver injury. Eosinophilia may be a considerable feature, particularly happening in male patients.
We report here a Crohn´s disease patient presenting with de novo hypergammaglobulinemia, circulating autoantibodies and elevated transaminase levels. He also had significant peripheral eosinophilia and elevated immunoglobulin E levels at diagnosis. The pathology findings from liver biopsy were compatible with autoimmune hepatitis with eosinophilic infiltration.
This is the first report of autoimmune hepatitis with exuberant eosinophilic infiltration in the liver and bone marrow, described in a patient with Crohn's disease.
自身免疫性肝炎是一种病因不明的慢性肝病。它由相关的免疫学方面和免疫介导的肝损伤组成。嗜酸性粒细胞增多可能是一个显著特征，尤其在男性患者中发生。
我们在此报告一名克罗恩病患者，其出现了新发高球蛋白血症、循环自身抗体和转氨酶水平升高。他在诊断时还伴有显著的外周血嗜酸性粒细胞增多和免疫球蛋白E水平升高。肝活检的病理结果与伴有嗜酸性粒细胞浸润的自身免疫性肝炎相符。
这是首例在克罗恩病患者中描述的伴有肝脏和骨髓中大量嗜酸性粒细胞浸润的自身免疫性肝炎报告。
