Mukai Kanae, Nakatani Toshio
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
J Tissue Viability. 2024 Nov;33(4):616-624. doi: 10.1016/j.jtv.2024.09.011. Epub 2024 Sep 28.
To evaluate the process of cutaneous wound healing, experiments have been conducted. However, to date, what modern wound dressings are suitable remains unclear. Therefore, this study aimed to compare the healing process in different modern wound dressings to determine their suitability in experimental acute wound and chronic diabetic wound.
Twelve C57BL/6J mice and eleven db/db mice were subjected to full-thickness wound injuries. The mice were divided into the following four groups: hydrocolloid, form, film, and gauze groups in both wild-type and db/db mice. Wound healing was assessed until day 14.
In the wild-type groups, all wounds were healed and completed re-epithelialization by day 14. However, the wound surface was dry, and the periwound was hypercontracted in the wild-type-form and wild-type-gauze groups. In the db/db groups, wounds were not healed until day 14. Wound exudates in the db/db-hydrocolloid group were abundant and gradually increased until day 14. Wound exudates in the db/db-film group were present until day 14. Conversely, in the db/db-form and db/db-gauze groups, the wound surface was dry, and the periwound was hypercontracted.
These results showed that hydrocolloid and film dressings are suitable modern wound dressings for the mice wound models of acute wound and chronic diabetic wound. Moreover, using either hydrocolloid or film dressing depending on the purpose of the study on cutaneous wound healing in diabetes is necessary.
为了评估皮肤伤口愈合过程，已开展了相关实验。然而，迄今为止，何种现代伤口敷料适用仍不明确。因此，本研究旨在比较不同现代伤口敷料的愈合过程，以确定它们在实验性急性伤口和慢性糖尿病伤口中的适用性。
对12只C57BL/6J小鼠和11只db/db小鼠进行全层伤口损伤。将小鼠分为以下四组：野生型和db/db小鼠的水胶体组、泡沫组、薄膜组和纱布组。评估伤口愈合情况直至第14天。
在野生型组中，所有伤口在第14天均愈合并完成重新上皮化。然而，野生型泡沫组和野生型纱布组的伤口表面干燥，伤口周围组织过度收缩。在db/db组中，伤口直到第14天仍未愈合。db/db水胶体组的伤口渗出物丰富，直至第14天逐渐增加。db/db薄膜组的伤口渗出物持续至第14天。相反，在db/db泡沫组和db/db纱布组中，伤口表面干燥，伤口周围组织过度收缩。
这些结果表明，水胶体敷料和薄膜敷料是适用于急性伤口和慢性糖尿病伤口小鼠伤口模型的现代伤口敷料。此外，根据糖尿病皮肤伤口愈合研究的目的，选择使用水胶体敷料或薄膜敷料是必要的。
