Snowden Stuart G, Koulman Albert, Gaser Christian, la Fleur Susanne E, Roseboom Tessa J, Korosi Aniko, de Rooij Susanne R
Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Level 4 Pathology, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Department of Biological Sciences, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK.
NPJ Aging. 2024 Sep 30;10(1):42. doi: 10.1038/s41514-024-00169-x.
Prenatal adversity affects cognitive and brain aging. Both lipid and leptin concentrations may be involved. We investigated if prenatal undernutrition is associated with a specific blood lipid profile and/or leptin concentrations, and if these relate to cognitive function and brain aging. 801 plasma samples of members of the Dutch famine birth cohort were assessed for lipidomics and leptin at age 58. Cognitive performance was measured with a Stroop task at 58, and MRI-based BrainAGE was derived in a subsample at 68. Out of 259 lipid signals, a signature of five identified individuals who were undernourished prenatally. These five lipids were not associated with cognitive performance, but three were predictive of BrainAGE. Leptin was not associated with prenatal famine exposure, Stroop performance, or BrainAGE. In conclusion, prenatal undernutrition was associated with an altered lipid profile predictive of BrainAGE 10 years later, demonstrating the potential of lipid profiles as early biomarkers for accelerated brain aging.
产前逆境会影响认知和大脑衰老。脂质和瘦素浓度可能都与之有关。我们调查了产前营养不足是否与特定的血脂谱和/或瘦素浓度相关，以及这些是否与认知功能和大脑衰老有关。对荷兰饥荒出生队列成员的801份血浆样本在58岁时进行了脂质组学和瘦素评估。在58岁时用Stroop任务测量认知表现，并在68岁时从一个子样本中得出基于磁共振成像的脑龄（BrainAGE）。在259个脂质信号中，确定了5个产前营养不良个体的特征。这5种脂质与认知表现无关，但其中3种可预测脑龄。瘦素与产前饥荒暴露、Stroop表现或脑龄无关。总之，产前营养不足与10年后可预测脑龄的血脂谱改变有关，这表明血脂谱有潜力作为加速大脑衰老的早期生物标志物。
