Department of Nursing, Seojeong University, Yangju-Si, Gyeonggi-Do, Republic of Korea.
Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, 50-1 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea.
Sci Rep. 2024 Sep 30;14(1):22702. doi: 10.1038/s41598-024-72403-1.
The metabolic syndrome (MetS) is a group of diseases conceptualized as a clustering of risk factors, with the risks of developing MetS in women varying significantly before and after menopause. This study investigated MetS clustering patterns and their association with cardiovascular disease (CVD) risk among post-menopausal women (n = 2479) using data from the Korean Genome Epidemiology Study. Using latent class analysis, three groups emerged: diabetic (5.6%), hypertensive (35.2%), and low-risk (59.2%). Relative to the low-risk group, the diabetic group demonstrated associations with older age, a family history of chronic disease, an increased Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), an elevated white blood cell (WBC) count, experience with hysterectomy, being a non-drinker, more physical activity, and excessive sleep. The hypertensive group was associated with older age, lower monthly income, a family history of chronic disease, increased HOMA-IR, a higher WBC count, more physical activity, and excessive sleep. The diabetic and hypertensive groups had a significantly higher CVD risk than the low-risk group (diabetic: odds ratio [OR] = 2.41 [1.11, 5.27]; hypertensive: OR = 2.46 [1.33, 4.55]). This study identified potential markers for MetS screening in post-menopausal women, highlighting the need for early intervention and personalized healthcare for middle-aged women to reduce CVD risk following menopause.
代谢综合征（Metabolic Syndrome，MetS）是一组疾病，被认为是一组风险因素的聚集，女性在绝经前后发生 MetS 的风险差异很大。本研究使用韩国基因组流行病学研究的数据，调查了绝经后妇女（n=2479）的 MetS 聚类模式及其与心血管疾病（Cardiovascular Disease，CVD）风险的关系。采用潜在类别分析，共出现三组：糖尿病（5.6%）、高血压（35.2%）和低危（59.2%）。与低危组相比，糖尿病组与年龄较大、慢性疾病家族史、胰岛素抵抗评估模型（HOMA-IR）升高、白细胞（WBC）计数升高、子宫切除术史、非饮酒者、更多的身体活动和过度睡眠有关。高血压组与年龄较大、月收入较低、慢性疾病家族史、HOMA-IR 升高、WBC 计数升高、更多的身体活动和过度睡眠有关。糖尿病组和高血压组的 CVD 风险明显高于低危组（糖尿病：比值比 [OR] = 2.41 [1.11, 5.27]；高血压：OR = 2.46 [1.33, 4.55]）。本研究确定了绝经后妇女 MetS 筛查的潜在标志物，强调需要对中年妇女进行早期干预和个性化医疗保健，以降低绝经后 CVD 风险。
