Institute of Clinical Electrocardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
BMC Psychiatry. 2024 Sep 30;24(1):644. doi: 10.1186/s12888-024-06117-z.
Depressive symptoms are comorbid with coronary heart disease (CHD). There is a controversial debate about whether screening and intervention for depressive symptoms could improve cardiovascular prognosis. This study characterizes the prevalence, characteristics, cardiovascular prognosis and management need of depressive symptoms among CHD patients.
CHD patients were recruited between November 18, 2020 and November 26, 2021. Depressive symptoms were evaluated with the Patient Health Questionnaire (PHQ-9). During the 12-month follow-up, cardiovascular disease (CVD) was the endpoint. Time-to-event data were estimated by Kaplan-Meier curves and Cox models.
Of 582 patients (25% women), 21.0% had mild depressive symptoms, and 7.5% had moderate-to-severe depressive symptoms during hospitalization. Mild and moderate-to-severe depressive symptoms were risk factor-adjusted predictors of the primary composite endpoints (adjusted HR = 2.20; 95%CI 1.19-4.03, and adjusted HR = 2.70; 95%CI 1.23-5.59, respectively). Platelet count and low-density lipoprotein were higher in mild depressive symptoms compared to no depressive symptoms.
Depressive symptoms are prevalent in CHD patients. Mild and moderate-to-severe depressive symptoms are associated with higher risk of further CVD in CHD patients. Platelet function and behavioral mechanisms may contribute to this association.
This research was registered at https://www.chictr.org.cn . Full data of first registration is 11/09/2020. The registration number is ChiCTR2000038139.
抑郁症状与冠心病（CHD）共病。关于是否筛查和干预抑郁症状可以改善心血管预后，存在争议。本研究描述了 CHD 患者中抑郁症状的患病率、特征、心血管预后和管理需求。
于 2020 年 11 月 18 日至 2021 年 11 月 26 日期间招募 CHD 患者。采用患者健康问卷（PHQ-9）评估抑郁症状。在 12 个月的随访期间，心血管疾病（CVD）是终点。使用 Kaplan-Meier 曲线和 Cox 模型估计时间事件数据。
在 582 名患者（25%为女性）中，住院期间 21.0%有轻度抑郁症状，7.5%有中重度抑郁症状。轻度和中重度抑郁症状是主要复合终点的风险因素调整预测因子（调整 HR=2.20；95%CI 1.19-4.03，和调整 HR=2.70；95%CI 1.23-5.59）。与无抑郁症状相比，轻度抑郁症状的血小板计数和低密度脂蛋白较高。
抑郁症状在 CHD 患者中普遍存在。轻度和中重度抑郁症状与 CHD 患者发生进一步 CVD 的风险增加相关。血小板功能和行为机制可能促成了这种关联。
本研究在 https://www.chictr.org.cn 上注册。首次注册的完整数据为 2020 年 11 月 9 日。注册号为 ChiCTR2000038139。
