Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, People's Republic of China.
Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, The College of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, 266071, Shandong, People's Republic of China.
Sci Rep. 2022 Aug 24;12(1):14419. doi: 10.1038/s41598-022-18457-5.
This cross-sectional study aimed to explore the combined effects of depression and obesity on ischemic heart disease and its subtypes. Data from the National Health and Nutrition Examination Survey 2007-2018 were used. A total of 29,050 participants aged 20 years or older were included in the analyses. Logistic regression models and restricted cubic spline models were applied to evaluate the associations between depression symptom and ischemic heart disease. There were significant correlations between depressive symptoms and ischemic heart disease [OR and 95% CI 2.44 (1.91, 3.10)] and its subtypes: coronary heart disease [2.32 (1.67, 3.23)], heart attack [2.18 (1.71, 2.78)], and angina [2.72 (1.96, 3.79)].The synergistic effects of depression with obesity (BMI ≥ 30) and central obesity (waist ≥ 102/88 cm for men/women) on ischemic heart disease were estimated and expressed using the relative excess risk due to interaction (RERI) and the attributable proportion due to interaction (AP). The RERI and AP with 95% CIs of depression and central obesity for ischemic heart disease were 1.10 (0.01, 2.19) and 0.35 (0.06, 0.64). When we analysed the other three subtypes of ischemic heart disease, we only found depressive symptoms and central obesity could have a meaningful synergistic effect on heart attack (RERI: 0.84 (- 0.28, 1.96) AP: (0.31 (0.00, 0.69)).
本横断面研究旨在探讨抑郁和肥胖对缺血性心脏病及其亚型的联合影响。使用了 2007-2018 年国家健康和营养检查调查的数据。共纳入 29050 名年龄在 20 岁及以上的参与者。应用逻辑回归模型和限制立方样条模型评估抑郁症状与缺血性心脏病之间的关联。抑郁症状与缺血性心脏病[比值比和 95%置信区间 2.44（1.91，3.10）]及其亚型之间存在显著相关性：冠心病[2.32（1.67，3.23）]、心脏病发作[2.18（1.71，2.78）]和心绞痛[2.72（1.96，3.79）]。通过相对超额风险（RERI）和交互归因比例（AP）来估计和表示抑郁与肥胖（BMI≥30）和中心性肥胖（男性腰围≥102/88cm，女性腰围≥88/80cm）对缺血性心脏病的协同作用。抑郁和中心性肥胖对缺血性心脏病的 RERI 和 AP 及其 95%置信区间分别为 1.10（0.01，2.19）和 0.35（0.06，0.64）。当我们分析缺血性心脏病的其他三个亚型时，我们只发现抑郁症状和中心性肥胖可能对心脏病发作有显著的协同作用（RERI：0.84（-0.28，1.96）AP：（0.31（0.00，0.69）））。
